EFFECTS OF ANTIBIOTICS AND OTHER DRUGS ON TOXIN PRODUCTION IN CLOSTRIDIUM-DIFFICILE INVITRO AND INVIVO

被引：18
作者：
BARC, MC
DEPITRE, C
CORTHIER, G
COLLIGNON, A
SU, WJ
BOURLIOUX, P
机构：
[1] CTR ETUD PHARMACEUT, FAC PHARM, MICROBIOL LAB, F-92296 CHATENAY MALABRY, FRANCE
[2] INRA, ECOL & PHYSIOL SYST DIGEST LAB, F-78352 JOUY EN JOSAS, FRANCE
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 06期
关键词：
D O I：
10.1128/AAC.36.6.1332
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In an attempt to understand more completely why patients treated with phenothiazines (chlorpromazine and cyamemazine), methotrexate, and certain antibiotics such as clindamycin have an increased risk of developing pseudomembranous colitis, the production of toxins A and B by Clostridium difficile in the presence of these drugs was measured in vitro as well as in vivo by using axenic mice. None of the drugs tested increased the production of toxins either in vitro or in vivo.
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页码：1332 / 1335
页数：4
相关论文
共 32 条
[1]   ANTIMICROBIAL AGENTS AND CLOSTRIDIUM-DIFFICILE IN ACUTE ENTERIC DISEASE - EPIDEMIOLOGICAL DATA FROM SWEDEN, 1980-1982 [J].
ARONSSON, B ;
MOLLBY, R ;
NORD, CE .
JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (03) :476-481
[2]  
AUDIGIER JC, 1982, REV PRATICIEN, V32, P2797
[3]  
BARTLETT JG, 1984, REV INFECT DIS, V6, pS235
[4]  
BARTLETT JG, 1981, JOHNS HOPKINS MED J, V149, P6
[5]  
BARTLETT JG, 1978, GASTROENTEROLOGY, V75, P778
[6]  
CALMAT A, 1982, COMMUNICATION ACTUAL
[7]   A ROLE FOR COLONIC STASIS IN THE PATHOGENESIS OF DISEASE RELATED TO CLOSTRIDIUM-DIFFICILE [J].
CHURCH, JM ;
FAZIO, VW .
DISEASES OF THE COLON & RECTUM, 1986, 29 (12) :804-809
[8]  
COLLIGNON A, 1988, PATHOL BIOL, V36, P754
[9]   MODULATION OF CYTO-TOXIN PRODUCTION BY CLOSTRIDIUM-DIFFICILE IN THE INTESTINAL TRACTS OF GNOTOBIOTIC MICE INOCULATED WITH VARIOUS HUMAN INTESTINAL BACTERIA [J].
CORTHIER, G ;
DUBOS, F ;
RAIBAUD, P .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1985, 49 (01) :250-252
[10]   CLOSTRIDIUM-DIFFICILE COLITIS ASSOCIATED WITH CANCER-CHEMOTHERAPY [J].
CUDMORE, MA ;
SILVA, J ;
FEKETY, R ;
LIEPMAN, MK ;
KIM, KH .
ARCHIVES OF INTERNAL MEDICINE, 1982, 142 (02) :333-335
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