TOXICITY OF 1,4-BIS(AMINOCYCLOHEXYL)METHANE

被引：0
作者：
KENNEDY, GL
机构：
[1] Haskell Laboratory for Toxicology and Industrial Medicine, Central Research and Development Department, E. I. du Pont de Nemours, Inc., Newark, Delaware, 19714, PO Box 50, Elkton Road
来源：
JOURNAL OF APPLIED TOXICOLOGY | 1991年 / 11卷 / 05期
关键词：
1,4-BIS(AMINOCYCLOHEXYL)METHANE; ACUTE ORAL TOXICITY; SKIN IRRITATION; RATS; GUINEA PIGS; RABBITS; DOGS; EYE IRRITATION; SENSITIZATION; REPEATED ORAL TOXICITY;
D O I：
10.1002/jat.2550110512
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
1,4-Bis(aminocyclohexyl)methane (PACM; CAS No. 1761-71-3) is a white solid considered for use in polymeric systems. PACM is moderately toxic systemically, with the acute oral lethal dose in rats between 670 and 1000 mg kg-1. PACM is a weak dermal sensitizer in the guinea pig. Instillation of as little as 10 mg of PACM to the rabbit eye produces severe injury. This damage could be permanent and was not reduced by rinsing the eye with water. Dogs given oral doses of 50 mg PACM kg-1 5 days per week for up to 18 months showed kidney and liver damage, along with local irritation of the gastrointestinal tract. The chemical is highly irritating and contact with it should be avoided.
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页码：367 / 371
页数：5
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