RECEPTOR INTERFERENCE GROUPS OF 20 RETROVIRUSES PLATING ON HUMAN-CELLS

被引:213
作者
SOMMERFELT, MA [1 ]
WEISS, RA [1 ]
机构
[1] INST CANC RES, CHESTER BEATTY LABS, FULHAM RD, LONDON SW3 6JB, ENGLAND
关键词
D O I
10.1016/0042-6822(90)90230-O
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The types of receptors on the surfaces of human and other mammalian cells for 13 C-type and 7 D-type retrovirus strains were determined by interference to the formation of syncytia and the plating of viral pseudotypes. All the D-type simian retroviruses (SRV-1-5, SMRV, PO-1-Lu) share a common receptor which is also utilized by the baboon and cat endogenous C-type viruses (BaEV, RD 114). Syncytial cross-interference was also observed in human cells between the gibbon ape leukemia/simian sarcoma associated viruses (GALV/SSAV) and feline leukemia virus subgroup B (FeLV-B). Amphotropic and xenotropic murine leukemia viruses (MLV-A, MLV-X), bovine leukemia virus (BLV), and FeLV-C infect human cells via unique cell surface receptors. Human T-cell leukemia viruses types 1 and 2 (HTLV-1, HTLV-2) share a common receptor with related chimpanzee and simian viruses (STLV). Thus seven distinct receptor groups were delineated on human cells for C-type and D-type retroviruses. © 1990.
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收藏
页码:58 / 69
页数:12
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