FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF GLIPIZIDE BY SOLID DISPERSION

The aim of the present research work was to enhance the solubility of Glipizide by solid dispersion method and to formulate a mouth dissolving tablet. Drugs are more frequently taken by oral administration. The solubility of Glipizide enhanced with different ratios of CCS by the kneading method. In-vitro release profile of solid dispersion obtained in Ph 6.8 phosphate buffer indicate that 100% drug release found within 20 min. These solid dispersions were directly compressed into tablets using sodium starch glycolate, crosspovidone and pregelatinised starch in different concentrations as a superdisintegrants. The prepared tablets containing the solid dispersion of Glipizide had sufficient strength of 1.5-2 kg/cm(2). The disintegrated in the oral cavity within 21 sec. contain crosspovidone (5%) as superdisintegrant.