PREVALENCE OF LEGIONELLA-PNEUMOPHILA SEROGROUP-1 ANTIBODIES IN BLOOD-DONORS

被引：12

作者：

FRANZIN, L

SCRAMUZZA, F

机构：

[1] Infectious Diseases Institute, University of Turin, Turin, I-10149

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1995年 / 11卷 / 04期

关键词：

ANTIBODIES; BLOOD DONORS; LEGIONELLA PNEUMOPHILA;

D O I：

10.1007/BF01721236

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The prevalence of anti-legionella pneumophila serogroup 1 antibodies in 777 blood donors of the Turin area was determined by the indirect immunofluorescence assay (IFA) and by the microagglutination test (MA). Low titers (IFA of 1/16 and MA of 1/8) were found in 0.3% of the subjects. A statistically significant difference was not observed by sex and by age for IFA titers, but was noted by sex for MA titers of greater than or equal to 1/4 (p< 0.05). The upper limit of normal titer was < 1/8 by IFA and < 1/4 by MA at 15% cutoff level and 1/8 by IFA and 1/4 by MA at 1% cutoff level. In conclusion, the prevalence of antibodies in the Turin area was very low; IFA titers of greater than or equal to 1/64 and MA titers of > 1/16 can be considered as presumptive of infection in a single serum specimen of a patient with pneumonia; no change in the epidemiology of the disease was observed in the recent years.

引用

页码：475 / 478

页数：4

共 22 条

[1]

Wilkinson H.W., Fikes B.J., Cruce D.D., Indirect immunofluorescence test for serodiagnosis of Legionnaires disease: Evidence for serogroup diversity of Legionnaires disease bacterial antigens and for multiple specificity of human antibodies, J Clin Microbiol, 9, pp. 379-383, (1979)

[2]

Farshy C.E., Klein G.C., Feeley J.C., Detection of antibodies to Legionnaires' disease organism by microagglutination and microenzyme immunosorbent assay tests, J Clin Microbiol, 7, pp. 327-331, (1978)

[3]

Harrison T.G., Taylor A.G., A rapid microagglutination test for the diagnosis of Legionella pneumophila (serogroup 1) infection, J Clin Pathol, 35, pp. 1028-1031, (1982)

[4]

Castellani Pastoris M., Ciarrocchi S., Di Capua A., Temperanza A.M., Comparison of phenol- and heat-killed antigens in the indirect immunofluorescence test for serodiagnosis of Legionella pneumophila group 1 infections, J Clin Microbiol, 20, pp. 780-783, (1984)

[5]

Temperanza A.M., Di Capua A., Ciarrocchi S., Ciceroni L., Castellani Pastoris M., More experience on the microagglutination test in the diagnosis of Legionella pneumophila infection, Microbiologica, 9, pp. 71-79, (1986)

[6]

Glants SA, Statistica per discipline biomediche, pp. 100-102, (1988)

[7]

Wilkinson H.W., Cruce D.D., Broome C.V., Validation of Legionella pneumophila indirect immunofluorescence assay with epidemic sera, J Clin Microbiol, 13, pp. 139-146, (1981)

[8]

Wilkinson HW, Hospital-laboratory diagnosis of Legionella infections, pp. 23-25, (1987)

[9]

Harrison T.G., Dournon E., Taylor A.G., Evaluation of sensitivity of two serological tests for diagnosing pneumonia caused by Legionella pneumophila 1, J. Clin Pathol, 40, pp. 77-82, (1987)

[10]

Bornstein N., Fleurette J., Comparison of microagglutination with indirect immunofluorescence assay for the diagnosis of infection with Legionella pneumophila serogroup 1, Eur J Clin Microbiol Infect Dis, 2, pp. 335-339, (1983)

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