THE EFFECT OF CAPTOPRIL ON THE OXIDATION OF PLASMA-LIPOPROTEINS

被引：9
作者：
CLEARFIELD, MB
LEE, N
ARMSTRONG, L
DEFAZIO, P
KUDCHODKAR, BJ
LACKO, AG
机构：
[1] UNIV N TEXAS, HLTH SCI CTR, DEPT MED, FT WORTH, TX USA
[2] UNIV N TEXAS, HLTH SCI CTR, DEPT BIOCHEM & MOLEC BIOL, FT WORTH, TX USA
[3] UNIV N TEXAS, HLTH SCI CTR, HEART DIS PREVENT CLIN, FT WORTH, TX USA
来源：
PHARMACOLOGY & TOXICOLOGY | 1994年 / 75卷 / 3-4期
关键词：
D O I：
10.1111/j.1600-0773.1994.tb00350.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antihypertensive drug captopril was found to inhibit the oxidation of low density lipoproteins by copper in a dose dependent manner in vitro. Up to 65% inhibition of oxidation was observed at the concentration of 100 mu g/ml of captopril. During subsequent studies with patients, captopril protected low density lipoproteins against oxidation slightly better than enalapril, although this difference was nor, statistically significant. Captopril had no effect on the levels of Lp(a) as compared to the levels established during enalapril treatment.
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页码：218 / 221
页数：4
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