COMPARATIVE EFFECTS OF GROWTH-FACTORS ON FIBROBLASTS OF DUPUYTRENS TISSUE AND NORMAL PALMAR FASCIA

被引：49

作者：

ALIOTO, RJ

ROSIER, RN

BURTON, RI

PUZAS, JE

机构：

[1] Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1994年 / 19A卷 / 03期

关键词：

D O I：

10.1016/0363-5023(94)90059-0

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Recent experimental evidence implicates various growth factors in the pathophysiology of Dupuytren's disease. This study describes a technique to produce an in vitro cell culture system from both normal palmar fascia and Dupuytren's fascia. The cells were separately exposed to basic fibroblast growth factor (bFCF), transforming growth factor beta (TGF-beta), and platelet-derived growth factor (PDCF), after which the effects of these growth factors on proliferation rate and collagen production were determined. Basic FCF and PDCF were found to be mitogenic for both cell types, and TGF-beta was a potent stimulator of collagen production for both cell types. There were quantitative and qualitative differences between the cell types, with Dupuytren cells being more metabolically active and more sensitive to the growth factors tested. We present a theoretical model based on previous investigations and incorporating the contribution of growth factors as it relates to the pathophysiology of Dupuytren's disease.

引用

页码：442 / 452

页数：11

共 30 条

[1]

Legge, Dupuytren disease, Surg Annu, 17, pp. 355-368, (1985)

[2]

McFarlane, The current status of Dupuytren's disease, J Hand Surg, 8, pp. 703-708, (1983)

[3]

Kischer, Speer, Microvascular changes in Dupuytren's contracture, J Hand Surg, 9 A, pp. 58-62, (1984)

[4]

Murrell, Francis, Jowlett, Dupuytren's contracture: fine structure in relation to aetiology, J Hand Surg, 71 B, pp. 367-373, (1989)

[5]

Iwasaki, Muller, Stutte, Brennscheidt, Palmar fibromatosis (Dupuytren's contracture), Virchows Arch A [Pathol Anat] Histopathol, 405, pp. 41-53, (1984)

[6]

Waterfield, Altered growth regulation in cancer, Br Med Bull, 45, pp. 570-581, (1989)

[7]

Olashaw, Olson, Drozdoff, Pledger, Growth factors: their role in the control of cell proliferation and differentiation, Molecular and cellular approaches to the control of proliferation and differentiation, pp. 4-21, (1992)

[8]

Badalamente, Hurst, Grandia, Sampson, Platelet derived growth factor in Dupuytren's disease, J Hand Surg, 17 A, pp. 317-323, (1992)

[9]

Lappi, Martineau, Maher, Et al., Basic fibroblast growth factor in cells derived from Dupuytren's contracture: synthesis, presence, and implications for treatment of the disease, J Hand Surg, 17 A, pp. 324-332, (1992)

[10]

Baird, Esch, Mormeae, Et al., Molecular characterization of firbroblast growth factor: distribution and biological activities in various tissues, Recent Prog Horm Res, 42, pp. 143-205, (1986)

← 1 2 3 →