DETERMINATION OF 7-METHYLBENZ[C]ACRIDINES BY CAPILLARY GAS-CHROMATOGRAPHY WITH ELECTRON-CAPTURE DETECTION

被引：6
作者：
KAMATA, K
MOTOHASHI, N
MEYER, R
YAMAMOTO, Y
机构：
[1] MEIJI COLL PHARM,DEPT MED CHEM,TOKYO 188,JAPAN
[2] HERBERT LABS,IRVINE,CA 92715
[3] TOHOKU COLL PHARMACEUT SCI,DEPT MED CHEM,AOBA KU,SENDAI 981,JAPAN
来源：
JOURNAL OF CHROMATOGRAPHY | 1992年 / 596卷 / 02期
关键词：
D O I：
10.1016/0021-9673(92)85012-I
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive gas chromatographic procedure for the determination of 7-methylbenz[c]acridines (7-methyl-BAcs) is presented. The 7-methyl-BAcs are easily oxidized to 7-formylbenz[c]acridines (7-formyl-BAcs) with periodic acid in dimethyl sulfoxide. The 7-formyl-BAcs are then reacted directly with p-fluoroaniline by way of Schiff base formation. The Schiff bases are analyzed by gas chromatography using a 25-m HP-5 column with electron-capture detection. The electron-capture response for the Schiff bases is very sensitive and amounts down to 20 pg are easily detected. Mass spectral data for the Schiff bases obtained under electron impact conditions are also presented.
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页码：233 / 239
页数：7
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