GENOTOXICITY OF PLANT-EXTRACTS

被引：33

作者：

VARGAS, VMF ^{[1
]}

GUIDOBONO, RR ^{[1
]}

HENRIQUES, JAP ^{[1
]}

机构：

[1] UNIV FED RIO GRANDE SUL,INST BIOCIENCIAS,DEPT FISIOL FARMACOL & BIOFIS,BR-90049 PORTO ALEGRE,RS,BRAZIL

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1991年 / 86卷

关键词：

AMES TEST; FLAVONOIDS; TANNINS; PLANT EXTRACTS; ACHYROCLINE-SATUREOIDES; LUEHEA-DIVARICATA; BACCHARIS-ANOMALA;

D O I：

10.1590/S0074-02761991000600017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Aqueous extracts of seven species used in Brazilian popular medicine (Achyrocline satureoides, Iodina rhombifolia, Desmodium incanum, Baccharis anomala, Tibouchina asperior, Luehea divaricata, Maytenus ilicifolia) were screened to the presence of mutagenic activity in the Ames test (Salmonella/microsome). Positive results were obtained for A. satureoides, B. anomala and L. divaricata with microsomal activation. As shown elsewhere (Vargas et al., 1990) the metabolites of A. satureoides extract also show the capacity to induce prophage and/or SOS response in microscreen phage induction assay and SOS spot chromotest. The positive results were related to the presence of flavonoids and tannins in the aqueous extracts.

引用

页码：67 / 70

页数：4

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