CHARACTERIZATION OF STEROIDAL GLYCOSIDES FROM TYLOPHORA-SYLVATICA

被引：13

作者：

GNABRE, JN

PINNAS, JL

MARTIN, DG

MIZSAK, SA

KLOOSTERMAN, DA

BACZYNSKYJ, L

NIELSEN, JW

BATES, RB

HOFFMANN, JJ

KANE, VV

机构：

[1] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

[2] UNIV ARIZONA,ARIZONA HLTH SCI CTR,TUCSON,AZ 85724

[3] UNIV ARIZONA,COLL PHARM,TUCSON,AZ 85721

[4] JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218

[5] UPJOHN CO,KALAMAZOO,MI 49001

来源：

TETRAHEDRON | 1991年 / 47卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(01)80868-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new steroidal glycosides (tylophoroside 1 and its monoacetate acetyltylophoroside 2) from Tylophora sylvatica (Asclepiadaceae), a medicinal plant from the Ivory Coast, were characterized, largely by 2-D NMR methods. 1, C48H72O22, was found to have three sugars units connected by a vinyl ether linkage to the 3-position of a steroidal aglycone (a new feature in a natural product). The aglycone part contains a novel lactone ring attached at C-13, formed in nature after opening of the D-ring at the 14-15 bond. 1 and 2 have cardiotonic activity, and the aglycone tylogenin 3 is more active than the widely used dexamethasone in anti-allergic assays.

引用

页码：3545 / 3554

页数：10