THE RATE OF SUBSTRATE CYCLING BETWEEN FRUCTOSE 6-PHOSPHATE AND FRUCTOSE-1,6-BISPHOSPHATE IN SKELETAL-MUSCLE FROM COLD-EXPOSED, HYPERTHYROID OR ACUTELY EXERCISED RATS

被引：16

作者：

CHALLIS, RAJ

ARCH, JRS

NEWSHOLME, EA

机构：

[1] UNIV OXFORD, DEPT BIOCHEM, S PARKS RD, OXFORD OX1 3QU, ENGLAND

[2] BEECHAM PHARMACEUT, BIOSCI RES CTR, EPSOM KT18 5YG, SURREY, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1985年 / 231卷 / 01期

关键词：

D O I：

10.1042/bj2310217

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of cold-exposure, the hyperthyroid state and a single exercise bout in vivo on the maximal enzyme activities of 6-phosphofructokinase and fructose-1,6-bisphosphatase in vastus lateralis muscle and the rates of fructose 6-phosphate/fructose 1,6-bisphosphate cycling measured in epitrochlearis muscle in vitro were investigated. In all cases significant changes in substrate cycling rates were observed, whether in the absence of added hormones in vitro (acute exercise), or when stimulated by insulin plus adrenaline (cold-exposure), or with respect to the catecholamine-sensitivity of the cycling rate (the hyperthyroid state).

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页码：217 / 220

页数：4

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