DEPRESSION AND POTENTIATION OF THE SYNAPTIC TRANSMISSION BETWEEN A GRANULE CELL AND A PURKINJE-CELL IN RAT CEREBELLAR CULTURE

被引：103

作者：

HIRANO, T

机构：

[1] Department of Physiology, School of Medicine, Gunma University, Gunma

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 02期

关键词：

Cerebellum; Culture; Granule cell; Long-term depression; Motor learning; Purkinje cell; Synaptic plasticity;

D O I：

10.1016/0304-3940(90)90818-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both the depression and the potentiation of synaptic transmission between a cerebellar granule cell and a Purkinje cell, which are considered the cellular basis of motor learning, were established in a simple culture preparation. The repetitive stimulation of both a granule cell and an inferiorolivary neuron depressed the synaptic transmission, and the repetitive stimulation of only a granule cell potentiated the transmission. Thus, a simple model system, where detailed analysis of molecular and cellular mechanisms of synaptic plasticities can be performed, has been established. © 1990.

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页码：141 / 144

页数：4

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