Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression

被引：16
作者：
Moriam, Sofia [1 ]
Sobhani, Mahbub E. [1 ]
机构：
[1] Khulna Univ, Biotechnol & Genet Engn Discipline, Khulna, Bangladesh
来源：
GENETICS & EPIGENETICS | 2013年 / 5卷
关键词：
epigenetics; chronic stress; dopamine signaling; depression;
D O I：
10.4137/GEG.S11016
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factors lead many drugs to target Dopamine receptors in treating depressive disorders. In this review, we try to portray how chronic stress as an epigenetic factor changes the gene regulation pattern by interrupting Dopamine signaling mechanism.
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收藏
页码：11 / 16
页数：6
相关论文
共 34 条
  • [1] American Psychiatric Association, 2013, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425596
  • [2] An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Beaulieu, JM
    Sotnikova, TD
    Marion, S
    Lefkowitz, RJ
    Gainetdinov, RR
    Caron, MG
    [J]. CELL, 2005, 122 (02) : 261 - 273
  • [3] Decoding dopamine signaling
    Bibb, JA
    [J]. CELL, 2005, 122 (02) : 153 - 155
  • [4] Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch
    Bofill-Cardona, E
    Kudlacek, O
    Yang, Q
    Ahorn, H
    Freissmuth, M
    Nanoff, C
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (42) : 32672 - 32680
  • [5] DNA methylation and methyl-CpG binding proteins: developmental requirements and function
    Bogdanovic, Ozren
    Veenstra, Gert Jan C.
    [J]. CHROMOSOMA, 2009, 118 (05) : 549 - 565
  • [6] BUNNEY WE, 1965, ARCH GEN PSYCHIAT, V13, P483
  • [7] CARLSSON A, 1959, PHARMACOL REV, V11, P490
  • [8] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    Caspi, A
    Sugden, K
    Moffitt, TE
    Taylor, A
    Craig, IW
    Harrington, H
    McClay, J
    Mill, J
    Martin, J
    Braithwaite, A
    Poulton, R
    [J]. SCIENCE, 2003, 301 (5631) : 386 - 389
  • [9] Histone modification: the 'next wave' in cancer therapeutics
    Chung, D
    [J]. TRENDS IN MOLECULAR MEDICINE, 2002, 8 (04) : S10 - S11
  • [10] BIOCHEMISTRY OF AFFECTIVE DISORDERS
    COPPEN, A
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1967, 113 (504) : 1237 - +
1234