Dual antiplatelet therapy: optimal timing, management, and duration

被引：31

作者：

Sabouret, Pierre ^{[1
,2
]}

Rushton-Smith, Sophie K. ^{[3
]}

Kerneis, Mathieu ^{[1
,2
]}

Silvain, Johanne ^{[1
,2
]}

Collet, Jean-Philippe ^{[1
,2
]}

Montalescot, Gilles ^{[1
,2
]}

机构：

[1] Pierre & Marie Curie Univ, Pitie Salpetriere Hosp, AP HP, Inst Coeur, 47-83 Blvd Hop, F-75013 Paris, France

[2] ACTION Grp, New Delhi, India

[3] Thrombosis Res Inst, London, England

来源：

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | 2015年 / 1卷 / 03期

关键词：

Dual antiplatelet therapy; Acute coronary syndrome; Stents; Optimal duration;

D O I：

10.1093/ehjcvp/pvv015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet activation and aggregability play a key role in the genesis of arterial thrombus secondary to plaque rupture. For coronary patients, inhibition of platelet function is crucial to decrease the rate of major adverse cardiac events but may expose them to excess bleeding risk. Switching P2Y12 inhibitors is common, yet the clinical consequences are unknown. The aim of this review is to provide an overview of the evidence from randomized, clinical trials and epidemiological studies, with a focus on the optimal duration of dual antiplatelet therapy (DAPT) and appropriate agent and dose selection. The report discusses the latest evidence regarding switching therapies during DAPT, the potential benefits of a personalized strategy, management of the preoperative period, and other clinical perspectives in this complex and rapidly changing field. Ongoing trials will be useful to answer to some important unresolved questions.

引用

页码：198 / 204

页数：7

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