Dual antiplatelet therapy: optimal timing, management, and duration

被引：31

作者：

Sabouret, Pierre ^{[1
,2
]}

Rushton-Smith, Sophie K. ^{[3
]}

Kerneis, Mathieu ^{[1
,2
]}

Silvain, Johanne ^{[1
,2
]}

Collet, Jean-Philippe ^{[1
,2
]}

Montalescot, Gilles ^{[1
,2
]}

机构：

[1] Pierre & Marie Curie Univ, Pitie Salpetriere Hosp, AP HP, Inst Coeur, 47-83 Blvd Hop, F-75013 Paris, France

[2] ACTION Grp, New Delhi, India

[3] Thrombosis Res Inst, London, England

来源：

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | 2015年 / 1卷 / 03期

关键词：

Dual antiplatelet therapy; Acute coronary syndrome; Stents; Optimal duration;

D O I：

10.1093/ehjcvp/pvv015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet activation and aggregability play a key role in the genesis of arterial thrombus secondary to plaque rupture. For coronary patients, inhibition of platelet function is crucial to decrease the rate of major adverse cardiac events but may expose them to excess bleeding risk. Switching P2Y12 inhibitors is common, yet the clinical consequences are unknown. The aim of this review is to provide an overview of the evidence from randomized, clinical trials and epidemiological studies, with a focus on the optimal duration of dual antiplatelet therapy (DAPT) and appropriate agent and dose selection. The report discusses the latest evidence regarding switching therapies during DAPT, the potential benefits of a personalized strategy, management of the preoperative period, and other clinical perspectives in this complex and rapidly changing field. Ongoing trials will be useful to answer to some important unresolved questions.

引用

页码：198 / 204

页数：7

共 50 条

[1]

Amsterdam EA, 2014, J AM COLL CARDIOL, V64, P2713, DOI [10.1016/j.jacc.2014.10.011, 10.1016/j.jacc.2014.09.017]

[2] Pharmacodynamic Evaluation of Switching From Ticagrelor to Prasugrel in Patients With Stable Coronary Artery Disease Results of the SWAP-2 Study (Switching Anti Platelet-2) [J].

Angiolillo, Dominick J. ;

Curzen, Nicholas ;

Gurbel, Paul ;

Vaitkus, Paul ;

Lipkin, Fred ;

Li, Wei ;

Jakubowski, Joseph A. ;

Zettler, Marjorie ;

Effron, Mark B. ;

Trenk, Dietmar .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (15) :1500-1509

[3] In-Hospital Switching Between Clopidogrel and Prasugrel Among Patients With Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention Insights Into Contemporary Practice From the National Cardiovascular Data Registry [J].

Bagai, Akshay ;

Wang, Yongfei ;

Wang, Tracy Y. ;

Curtis, Jeptha P. ;

Gurm, Hitinder S. ;

Shah, Binita ;

Cheema, Asim N. ;

Peterson, Eric D. ;

Saucedo, Jorge F. ;

Granger, Christopher B. ;

Roe, Matthew T. ;

Bhatt, Deepak L. ;

McNamara, Robert L. ;

Alexander, Karen P. .

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2014, 7 (04) :585-593

[4] Slow Response to Clopidogrel Predicts Low Response [J].

Bellemain-Appaix, Anne ;

Montalescot, Gilles ;

Silvain, Johanne ;

Barthelemy, Olivier ;

Beygui, Farzin ;

Collet, Jean-Philippe ;

Sideris, Georges ;

Meuleman, Catherine ;

Bal-dit-Sollier, Claire ;

Lellouche, Nicolas ;

Ducrocq, Gregory ;

Slama, Michel ;

Milleron, Olivier ;

Henry, Patrick ;

Drouet, Ludovic .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (08) :815-822

[5] Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction [J].

Bonaca, Marc P. ;

Bhatt, Deepak L. ;

Cohen, Marc ;

Steg, Philippe Gabriel ;

Storey, Robert F. ;

Jensen, Eva C. ;

Magnani, Giulia ;

Bansilal, Sameer ;

Fish, M. Polly ;

Im, Kyungah ;

Bengtsson, Olof ;

Ophuis, Ton Oude ;

Budaj, Andrzej ;

Theroux, Pierre ;

Ruda, Mikhail ;

Hamm, Christian ;

Goto, Shinya ;

Spinar, Jindrich ;

Nicolau, Jose Carlos ;

Kiss, Robert G. ;

Murphy, Sabina A. ;

Wiviott, Stephen D. ;

Held, Peter ;

Braunwald, Eugene ;

Sabatine, Marc S. ;

Morin, Suzanne ;

Dantzer, Emily ;

Acquilano, Dayle ;

McGuire, Rachael L. ;

Gannon, Joseph B. ;

Gershman, Elaine ;

Ahlbom, Ann Maxe ;

Boberg, Barbro ;

Abola, Maria Teresa ;

Ardissino, Diego ;

Aylward, Philip ;

Corbalan, Ramon ;

Dalby, Anthony ;

Diaz, Rafael ;

Hu, Dayi ;

Isaza, Daniel ;

Kamensky, Gabriel ;

Kiss, Robert ;

Kontny, Frederic ;

Lopez-Sendon, Jose ;

Medina, Felix ;

Montalescot, Gilles ;

Nicolau, Jose ;

Paolasso, Ernesto ;

Parkhomenko, Alexander .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (19) :1791-1800

[6] Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate [J].

Bonello, Laurent ;

Tantry, Udaya S. ;

Marcucci, Rossella ;

Blindt, Ruediger ;

Angiolillo, Dominick J. ;

Becker, Richard ;

Bhatt, Deepak L. ;

Cattaneo, Marco ;

Collet, Jean Philippe ;

Cuisset, Thomas ;

Gachet, Christian ;

Montalescot, Gilles ;

Jennings, Lisa K. ;

Kereiakes, Dean ;

Sibbing, Dirk ;

Trenk, Dietmar ;

Van Werkum, Jochem W. ;

Paganelli, Franck ;

Price, Matthew J. ;

Waksman, Ron ;

Gurbel, Paul A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (12) :919-933

[7] Rationale and design of a randomized, double-blind, placebo-controlled trial of 6 versus 12 months clopidogrel therapy after implantation of a drug-eluting stent: The Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual Antiplatelet Therapy After Drug-Eluting Stenting (ISAR-SAFE) study [J].

Byrne, Robert A. ;

Schulz, Stefanie ;

Mehilli, Julinda ;

Ijima, Raisuke ;

Massberg, Steffen ;

Neumann, Franz-Josef ;

ten Berg, Jurrien M. ;

Schoemig, Albert ;

Kastrati, Adnan .

AMERICAN HEART JOURNAL, 2009, 157 (04) :620-624

[8] Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type [J].

Camenzind, Edoardo ;

Boersma, Eric ;

Wijns, William ;

Mauri, Laura ;

Rademaker-Havinga, Tessa ;

Ordoubadi, Farzin Fath ;

Suttorp, Maarten J. ;

Kurdi, Mohammad Al ;

Steg, Ph Gabriel .

EUROPEAN HEART JOURNAL, 2014, 35 (29) :1932-1948

[9] Comparison of ticagrelor with clopidogrel in patients with planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study [J].

Cannon, Christopher P. ;

Harrington, Robert A. ;

James, Stefan ;

Ardissino, Diego ;

Becker, Richard C. ;

Emanuelsson, Hakan ;

Husted, Steen ;

Katus, Hugo ;

Keltai, Matyas ;

Khurmi, Nardev S. ;

Kontny, Frederic ;

Lewis, Basil S. ;

Steg, Philippe Gabriel ;

Storey, Robert F. ;

Wojdyla, Daniel ;

Wallentin, Lars .

LANCET, 2010, 375 (9711) :283-293

[10] Platelet function monitoring in elderly patients on prasugrel after stenting for an acute coronary syndrome: Design of the randomized antarctic study [J].

Cayla, Guillaume ;

Cuisset, Thomas ;

Silvain, Johanne ;

Henry, Patrick ;

Leclercq, Florence ;

Carrie, Didier ;

Saint Etienne, Christophe ;

Belle, Loic ;

Range, Gregoire ;

Pouillot, Christophe ;

Varenne, Olivier ;

Van Belle, Eric ;

Boueri, Ziad ;

Motreff, Pascal ;

Elhadad, Simon ;

Delarche, Nicolas ;

El Mahmoud, Rami ;

Vicaut, Eric ;

Collet, Jean-Philippe ;

Montalescot, Gilles .

AMERICAN HEART JOURNAL, 2014, 168 (05) :674-681

← 1 2 3 4 5 →