IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia

被引：10

作者：

Hasegawa, Ho ^{[1
]}

Mine, Sohtaro ^{[2
]}

Hagiwara, Shotaro ^{[3
]}

机构：

[1] Natl Ctr Global Hlth & Med, Dept Nephrol, Tokyo, Japan

[2] Natl Ctr Global Hlth & Med, Dept Pathol, Tokyo, Japan

[3] Natl Ctr Global Hlth & Med, Dept Hematol, Tokyo, Japan

来源：

CLINICAL MEDICINE INSIGHTS-CASE REPORTS | 2015年 / 8卷

关键词：

IgG4-related disease; parathyroid hormone; autoimmune hemolysis;

D O I：

10.4137/CCRep.S25553

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 67-year-old man with elevated serum immunoglobulin G4 (IgG4) levels, systemic lymphadenopathy infiltrated by IgG4-positive plasma cells, and Coombs-positive autoimmune hemolytic anemia (AIHA) showed marked hypercalcemia. Although the intact parathyroid hormone (PTH) level was elevated, 99mTc-MIBI scintigraphy and thyroid ultrasonography revealed no evidence of primary hyperparathyroidism. Liver biopsy showed marked infiltration of IgG4-positive plasma cells, which confirmed the diagnosis of IgG4-related disease (IgG4-RD). Corticosteroid therapy was initiated, and subsequently, intact PTH and serum calcium levels gradually normalized. Transient hypercalcemia in a patient with AIHA may therefore be associated with IgG4-RD.

引用

页数：5

共 13 条

[1]

Al-Saif F, 2006, PANCREAS, V33, P316

[2] Riedel's Thyroiditis and Multifocal Fibrosclerosis Are Part of the IgG4-Related Systemic Disease Spectrum [J].

Dahlgren, Mollie ;

Khosroshahi, Arezou ;

Nielsen, G. Petur ;

Deshpande, Vikram ;

Stone, John H. .

ARTHRITIS CARE & RESEARCH, 2010, 62 (09) :1312-1318

[3] High serum IgG4 concentrations in patients with sclerosing pancreatitis. [J].

Hamano, H ;

Kawa, S ;

Horiuchi, A ;

Unno, H ;

Furuya, N ;

Akamatsu, T ;

Fukushima, M ;

Nikaido, T ;

Nakayama, K ;

Usuda, N ;

Kiyosawa, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :732-738

[4] A new clinicopathological entity of IgG4-related autoimmune disease [J].

Kamisawa, T ;

Funata, N ;

Hayashi, Y ;

Eishi, Y ;

Koike, M ;

Tsuruta, K ;

Okamoto, A ;

Egawa, N ;

Nakajima, H .

JOURNAL OF GASTROENTEROLOGY, 2003, 38 (10) :982-984

[5] Autoimmune pancreatitis and IgG4-related sclerosing disease [J].

Kamisawa, Terumi ;

Takuma, Kensuke ;

Egawa, Naoto ;

Tsuruta, Koji ;

Sasaki, Tsuneo .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2010, 7 (07) :401-409

[6] A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor [J].

Kifor, O ;

Moore, FD ;

Delaney, M ;

Garber, J ;

Hendy, GN ;

Butters, R ;

Gao, P ;

Cantor, TL ;

Kifor, I ;

Brown, EM ;

Wysolmerski, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :60-72

[7] An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations [J].

Makita, Noriko ;

Sato, Junichiro ;

Manaka, Katsunori ;

Shoji, Yuki ;

Oishi, Atsuro ;

Hashimoto, Makiko ;

Fujita, Toshiro ;

Iiri, Taroh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (13) :5443-5448

[8] Brief report - Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor [J].

Pallais, JC ;

Kifor, O ;

Chen, YB ;

Slovik, D ;

Brown, EM .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (04) :362-369

[9] Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic disease [J].

Saeki, Takako ;

Saito, Akihiko ;

Hiura, Tohru ;

Yamazaki, Hajime ;

Emura, Iwao ;

Ueno, Mitsuhiro ;

Miyamura, Syoji ;

Gejyo, Fumitake .

INTERNAL MEDICINE, 2006, 45 (03) :163-167

[10] MECHANISMS OF DISEASE IgG4-Related Disease [J].

Stone, John H. ;

Zen, Yoh ;

Deshpande, Vikram .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (06) :539-551

← 1 2 →