IMMUNOHISTOCHEMISTRY ANALYSIS OF PLATELET-DERIVED GROWTH FACTOR-A AND FACTOR-B CHAINS AND PLATELET-DERIVED GROWTH-FACTOR-ALPHA AND BETA-RECEPTOR EXPRESSION IN BENIGN PROSTATIC HYPERPLASIAS AND GLEASON-GRADED HUMAN PROSTATE ADENOCARCINOMAS

被引:0
作者
FUDGE, K
WANG, CY
STEARNS, ME
机构
[1] MED COLL PENN,DEPT PATHOL,PHILADELPHIA,PA 19129
[2] VET ADM MED CTR,PHILADELPHIA,PA 19104
[3] HARVARD UNIV,SCH MED,DIV CELLULAR & MOLEC BIOL,BOSTON,MA
[4] DANA FARBER CANC INST,BOSTON,MA
关键词
ADENOCARCINOMA; PDGF A/B; PDGF RECEPTORS; PROSTATE CANCER; IMMUNOLABELING; GLEASON GRADING;
D O I
暂无
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The purpose of this study was to determine whether changes in the expression of platelet-derived growth factor (PDGF) and its receptors were associated with prostate cancer. Peroxidase-anti-peroxidase-immunoperoxidase labeling was used to detect the A and B chains and alpha and beta receptors of PDGF in 5 benign prostatic hyperplasias and 13 human prostate adenocarcinomas (Gleason grades 2 to 9). In all 5 benign prostatic hyperplasias, none of the PDGF antibodies (even at high titers, 1:50 dilutions) labeled the epithelial or the stromal cells. In adenocarcinomas, the A chain and alpha receptor antibodies labeled both epithelial and stromal cells. The intensity of the staining was relatively high in low Gleason grade (<6) and low in high Gleason grade (>7) tissue; however, the B chain and beta receptor antibodies failed to label either epithelial or stromal cells in any of the 13 adenocarcinomas. The data suggest that PDGF A and alpha receptor genes may be preferentially turned on in epithelial and stromal prostate tumor cells.
引用
收藏
页码:549 / 554
页数:6
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