ASYMMETRIC DEPROTONATION AS AN EFFICIENT ENANTIOSELECTIVE PREPARATION OF FUNCTIONALIZED SECONDARY ALCOHOLS

被引：22
作者：
KNOCHEL, P
机构：
[1] Fachbereich Chemie, Philipps‐Universität, Marburg, D-W-3550, Hans‐Meerwein‐Strasse
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 11期
关键词：
D O I：
10.1002/anie.199214591
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A reaction with organolithium compounds and the chiral amine (-)-sparteine deprotonates carbamates such as 1 in the alpha-position forming chiral lithio compounds 2, as shown by D. Hoppe et al. [Eq. (a)]. These react with high stereoselectivity with a variety of electrophiles to yield nonracemic, chiral compounds (see also the communication on p. 1505 ff). R1 = alkenyl, R2 = C(O)NiPr2, R3 = nBuLi.
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页码：1459 / 1461
页数：3
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