AGING - CAUSES AND DEFENSES

被引：37
作者：
MARTIN, GR
DANNER, DB
HOLBROOK, NJ
机构：
[1] Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore
来源：
ANNUAL REVIEW OF MEDICINE | 1993年 / 44卷
关键词：
SENESCENCE; TELOMERES; MITOCHONDRIAL DNA; HEAT SHOCK RESPONSE;
D O I：
10.1146/annurev.me.44.020193.002223
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent studies have shown that chromosomes shorten as cells divide and become senescent. Also, deletions in mitochondrial DNA increase markedly with advancing age, presumably secondary to damage from oxygen radicals. Since host defenses against environmental factors also become attenuated, the molecular damage associated with aging may increasingly perturb normal homeostasis and increase the susceptibility to disease and disability. Such age-associated dysfunctions can be targeted and interrupted.
引用
收藏
页码：419 / 429
页数：11
相关论文
共 45 条
[1]   ENDOGENOUS DNA DAMAGE AS RELATED TO CANCER AND AGING [J].
AMES, BN .
MUTATION RESEARCH, 1989, 214 (01) :41-46
[2]  
BAYREUTHER K, 1991, MUTAT RES, V256, P223
[3]   DOES IMPAIRMENT OF ENERGY-METABOLISM RESULT IN EXCITOTOXIC NEURONAL DEATH IN NEURODEGENERATIVE ILLNESSES [J].
BEAL, MF .
ANNALS OF NEUROLOGY, 1992, 31 (02) :119-130
[4]   STRUCTURE AND FUNCTION OF TELOMERES [J].
BLACKBURN, EH .
NATURE, 1991, 350 (6319) :569-573
[5]   STRESS-INDUCED HEAT-SHOCK PROTEIN-70 EXPRESSION IN ADRENAL-CORTEX - AN ADRENOCORTICOTROPIC HORMONE-SENSITIVE, AGE-DEPENDENT RESPONSE [J].
BLAKE, MJ ;
UDELSMAN, R ;
FEULNER, GJ ;
NORTON, DD ;
HOLBROOK, NJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9873-9877
[6]   GLYCOSYLATION PRODUCTS AS TOXIC MEDIATORS OF DIABETIC COMPLICATIONS [J].
BROWNLEE, M .
ANNUAL REVIEW OF MEDICINE, 1991, 42 :159-166
[7]   REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE [J].
CARNEY, JM ;
STARKEREED, PE ;
OLIVER, CN ;
LANDUM, RW ;
CHENG, MS ;
WU, JF ;
FLOYD, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3633-3636
[8]   TELOMERE SHORTENING ASSOCIATED WITH CHROMOSOME INSTABILITY IS ARRESTED IN IMMORTAL CELLS WHICH EXPRESS TELOMERASE ACTIVITY [J].
COUNTER, CM ;
AVILION, AA ;
LEFEUVRE, CE ;
STEWART, NG ;
GREIDER, CW ;
HARLEY, CB ;
BACCHETTI, S .
EMBO JOURNAL, 1992, 11 (05) :1921-1929
[9]   HUMAN TELOMERES ARE ATTACHED TO THE NUCLEAR MATRIX [J].
DELANGE, T .
EMBO JOURNAL, 1992, 11 (02) :717-724
[10]   REDOX REDUX - THE CONTROL OF OXIDATIVE STRESS RESPONSES [J].
DEMPLE, B ;
AMABILECUEVAS, CF .
CELL, 1991, 67 (05) :837-839
12345