PROGNOSTIC VALUE OF ONCOPROTEINS FOR THE SURVIVAL OF PATIENTS WITH NONSMALL CELL LUNG CARCINOMAS

被引：0
作者：
VOLM, M [1 ]
DRINGS, P [1 ]
MATTERN, J [1 ]
WODRICH, W [1 ]
机构：
[1] THORAX CLIN HEIDELBERG ROHRBACH,W-6900 HEIDELBERG,GERMANY
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1993年 / 2卷 / 05期
关键词：
ONCOPROTEINS; IMMUNOHISTOCHEMISTRY; NONSMALL CELL LUNG CARCINOMAS; PROGNOSIS; SURVIVAL;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Patients with non-small cell lung carcinomas whose tumors showed an overexpression of the oncogenes c-fos and c-N-ras at the protein level had significantly shorter survival times than those without overexpression of these oncogene products. (c-fos: p=0.0002, c-N-ras: p=0.002). Multivariate analysis showed that expression of proteins coded by c-fos and c-N-ras is a significant prognostic factor in addition to tumor staging and DNA ploidy. The prognostic value is improved by combining the expression of c-fos and c-N-ras products. A significant correlation between the expression of c-fos and c-N-ras products and the tumor take rate in nude mice was found.
引用
收藏
页码：767 / 772
页数：6
相关论文
共 31 条
  • [1] BAK M, 1990, EUR UROL, V17, P72
  • [2] BIRRER MJ, 1989, ANNU REV MED, V40, P305
  • [3] CARR DT, 1977, LUNG CANCER CLIN DIA, P151
  • [4] THE CURRENT STATE OF ONCOGENES AND CANCER - EXPERIMENTAL APPROACHES FOR ANALYZING ONCOGENETIC EVENTS IN HUMAN CANCER
    CHIAO, PJ
    BISCHOFF, FZ
    STRONG, LC
    TAINSKY, MA
    [J]. CANCER AND METASTASIS REVIEWS, 1990, 9 (01) : 63 - 80
  • [5] COX DR, 1972, J R STAT SOC B, V34, P187
  • [6] DETECTION OF FOS PROTEIN DURING OSTEOGENESIS BY MONOCLONAL-ANTIBODIES
    DETOGNI, P
    NIMAN, H
    RAYMOND, V
    SAWCHENKO, P
    VERMA, IM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) : 2251 - 2256
  • [7] EDLER L, 1980, STAT NEWSLETTER, V6, P44
  • [8] EFFERTH T, 1992, CANCER DETECT PREV, V16, P237
  • [9] FIELD JK, 1990, ANTICANCER RES, V10, P1
  • [10] GEHAN EA, 1965, BIOMETRIKA, V52, P203, DOI 10.1093/biomet/52.1-2.203
1234