IMBALANCE OF CD4+CD29+ AND CD4+CD45RA+ T-HELPER CELL SUBSETS IN PERIPHERAL-BLOOD OF PATIENTS WITH SEVERE ATOPIC-DERMATITIS

被引：6
|
作者：
JUNG, K [1 ]
BITTRICH, A [1 ]
KLIMMEK, V [1 ]
SCHUBERT, H [1 ]
机构：
[1] MED HSCH ERFURT,IMMUNOL ABT,O-5082 ERFURT,GERMANY
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 1993年 / 285卷 / 03期
关键词：
ATOPIC DERMATITIS; CD4+ MEMORY T-CELLS; CD4+ NAIVE T-CELLS;
D O I：
10.1007/BF01112915
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
To determine the proportion of T-helper cell subsets in the peripheral blood we studied 16 patients with mild, moderate and severe atopic dermatitis. Lymphocytes were isolated from heparinized peripheral blood and analysed by two-colour flow cytometry. Patients with severe atopic dermatitis had a decreased CD4 + CD29 +: CD4 + CD45RA + ratio (p < 0.01). We found a decreased absolute number of CD4 + CD29 + cells (p < 0.05) and an increased absolute number of CD4 + CD45RA + cells (p < 0.05) in the peripheral blood. No significant changes in the CD4 + CD29 +: CD4 + CD45RA + ratio were found in the peripheral blood of patients with clinically mild or moderate atopic dermatitis.
引用
收藏
页码：135 / 139
页数：5
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