IMBALANCE OF CD4+CD29+ AND CD4+CD45RA+ T-HELPER CELL SUBSETS IN PERIPHERAL-BLOOD OF PATIENTS WITH SEVERE ATOPIC-DERMATITIS

被引：6
|
作者：
JUNG, K [1 ]
BITTRICH, A [1 ]
KLIMMEK, V [1 ]
SCHUBERT, H [1 ]
机构：
[1] MED HSCH ERFURT,IMMUNOL ABT,O-5082 ERFURT,GERMANY
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 1993年 / 285卷 / 03期
关键词：
ATOPIC DERMATITIS; CD4+ MEMORY T-CELLS; CD4+ NAIVE T-CELLS;
D O I：
10.1007/BF01112915
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
To determine the proportion of T-helper cell subsets in the peripheral blood we studied 16 patients with mild, moderate and severe atopic dermatitis. Lymphocytes were isolated from heparinized peripheral blood and analysed by two-colour flow cytometry. Patients with severe atopic dermatitis had a decreased CD4 + CD29 +: CD4 + CD45RA + ratio (p < 0.01). We found a decreased absolute number of CD4 + CD29 + cells (p < 0.05) and an increased absolute number of CD4 + CD45RA + cells (p < 0.05) in the peripheral blood. No significant changes in the CD4 + CD29 +: CD4 + CD45RA + ratio were found in the peripheral blood of patients with clinically mild or moderate atopic dermatitis.
引用
收藏
页码：135 / 139
页数：5
相关论文
共 50 条
  • [21] Identification of non-naïve CD4+CD45RA+ T cell subsets in adult allogeneic haematopoietic cell transplant recipients
    P R Fallen
    R F Duarte
    L McGreavey
    M Potter
    M Ethell
    H G Prentice
    J A Madrigal
    P J Travers
    Bone Marrow Transplantation, 2003, 32 : 609 - 616
  • [22] CD45RA EXPRESSION IS REGULATED BY CELL ACTIVATION IN A CD4+CD45RA+(2H4+) HUMAN SUPPRESSOR-CELL LINE
    ROTHSTEIN, D
    SCHLOSSMAN, SF
    MORIMOTO, C
    KIDNEY INTERNATIONAL, 1990, 37 (01) : 429 - 429
  • [23] DIFFERENTIATION AND CD23 EXPRESSION OF PERIPHERAL-BLOOD MONOCYTES IN PATIENTS WITH ATOPIC-DERMATITIS
    BUCKLEY, C
    RUSTIN, MHA
    IVISON, C
    POULTER, LW
    BRITISH JOURNAL OF DERMATOLOGY, 1995, 133 (05) : 757 - 763
  • [24] DEFICIENCY OF SUPPRESSOR-INDUCER (CD4+CD45RA+) T-CELLS IN AUTISM
    WARREN, RP
    YONK, LJ
    BURGER, RA
    COLE, P
    ODELL, JD
    WARREN, WL
    WHITE, E
    SINGH, VK
    IMMUNOLOGICAL INVESTIGATIONS, 1990, 19 (03) : 245 - 251
  • [25] CHARACTERIZATION OF INFILTRATING CD4+ CELLS IN ATOPIC-DERMATITIS USING CD45R AND CD29 MONOCLONAL-ANTIBODIES
    WATANABE, K
    KONDO, N
    FUKUTOMI, O
    TAKAMI, T
    AGATA, H
    ORII, T
    ANNALS OF ALLERGY, 1994, 72 (01): : 39 - 44
  • [26] The tetraspanin CD9 is preferentially expressed on the human CD4+CD45RA+ naive T cell population and is involved in T cell activation
    Kobayashi, H
    Hosono, O
    Iwata, S
    Kawasaki, H
    Kuwana, M
    Tanaka, H
    Dang, NH
    Morimoto, C
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 137 (01): : 101 - 108
  • [27] Characteristics of peripheral blood CD4+CD25+ regulatory T cells and related cytokines in severe atopic dermatitis
    Yun-Ying Zhang
    Ao-Xue Wang
    Lu Xu
    Nan Shen
    Jie Zhu
    Cai-Xia Tu
    European Journal of Dermatology, 2016, 26 : 240 - 246
  • [28] Characteristics of peripheral blood CD4+CD25+regulatory T cells and related cytokines in severe atopic dermatitis
    Zhang, Yun-Ying
    Wang, Ao-Xue
    Xu, Lu
    Shen, Nan
    Zhu, Jie
    Tu, Cai-Xia
    EUROPEAN JOURNAL OF DERMATOLOGY, 2016, 26 (03) : 240 - 246
  • [29] CYCLIC REGULATION OF CD45 ISOFORM EXPRESSION IN A LONG-TERM HUMAN CD4+CD45RA+ T-CELL LINE
    ROTHSTEIN, DM
    YAMADA, A
    SCHLOSSMAN, SF
    MORIMOTO, C
    JOURNAL OF IMMUNOLOGY, 1991, 146 (04): : 1175 - 1183
  • [30] Decreases in CD8+T, naive (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume
    Nakata, Akinori
    Araki, Shunichi
    Park, Sang-Hwoi
    Park, Jong-Tae
    Kim, Dae-Sung
    Park, Hee-Chan
    Yokoyama, Kazuhito
    INDUSTRIAL HEALTH, 2006, 44 (04) : 592 - 597
12345