IMBALANCE OF CD4+CD29+ AND CD4+CD45RA+ T-HELPER CELL SUBSETS IN PERIPHERAL-BLOOD OF PATIENTS WITH SEVERE ATOPIC-DERMATITIS

被引：6
|
作者：
JUNG, K [1 ]
BITTRICH, A [1 ]
KLIMMEK, V [1 ]
SCHUBERT, H [1 ]
机构：
[1] MED HSCH ERFURT,IMMUNOL ABT,O-5082 ERFURT,GERMANY
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 1993年 / 285卷 / 03期
关键词：
ATOPIC DERMATITIS; CD4+ MEMORY T-CELLS; CD4+ NAIVE T-CELLS;
D O I：
10.1007/BF01112915
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
To determine the proportion of T-helper cell subsets in the peripheral blood we studied 16 patients with mild, moderate and severe atopic dermatitis. Lymphocytes were isolated from heparinized peripheral blood and analysed by two-colour flow cytometry. Patients with severe atopic dermatitis had a decreased CD4 + CD29 +: CD4 + CD45RA + ratio (p < 0.01). We found a decreased absolute number of CD4 + CD29 + cells (p < 0.05) and an increased absolute number of CD4 + CD45RA + cells (p < 0.05) in the peripheral blood. No significant changes in the CD4 + CD29 +: CD4 + CD45RA + ratio were found in the peripheral blood of patients with clinically mild or moderate atopic dermatitis.
引用
收藏
页码：135 / 139
页数：5
相关论文
共 50 条
  • [1] IMBALANCE OF CD4+CD45R+ AND CD4+CD29+ T-HELPER CELL SUBSETS IN PATIENTS WITH ATOPIC DISEASES
    SCHAUER, U
    JUNG, T
    HEYMANNS, J
    RIEGER, CHL
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1991, 83 (01): : 25 - 29
  • [2] DIFFERENTIAL AGE-CHANGE IN THE NUMBERS OF CD4+CD45RA+ AND CD4+CD29+ T-CELL SUBSETS IN HUMAN PERIPHERAL-BLOOD
    UTSUYAMA, M
    HIROKAWA, K
    KURASHIMA, C
    FUKAYAMA, M
    INAMATSU, T
    SUZUKI, K
    HASHIMOTO, W
    SATO, K
    MECHANISMS OF AGEING AND DEVELOPMENT, 1992, 63 (01) : 57 - 68
  • [3] Increase in memory (CD4+CD29+ and CD4+CD45RO+)T and naive (CD4+CD45RA+) T-cell subpopulations in smokers
    Tanigawa, T
    Araki, S
    Nakata, A
    Kitamura, F
    Yasumoto, M
    Sakurai, S
    Kiuchi, T
    ARCHIVES OF ENVIRONMENTAL HEALTH, 1998, 53 (06): : 378 - 383
  • [4] Changes in the subpopulations of helper/inducer T-cells (CD4+CD29+ and CD4+CD45RA+) after pediatric cardiac surgery
    Oku, S
    Itano, Y
    Iwasaki, T
    Takeuchi, M
    Morita, K
    Hirakawa, M
    ANESTHESIA AND ANALGESIA, 1997, 84 : S115 - S115
  • [5] DIFFERENTIAL RESPONSES OF CD4+CD45RA+ AND CD4+CD29+ SUBSETS TO ACTIVATED CD8+ CELLS - ENHANCED STIMULATION OF THE CD4+CD45RA+ SUBSET BY CELLS FROM PATIENTS WITH MULTIPLE-SCLEROSIS
    FREEDMAN, MS
    BLAIN, M
    ANTEL, JP
    CELLULAR IMMUNOLOGY, 1991, 133 (02) : 306 - 316
  • [6] Effects of job strain on helper-inducer (CD4+CD29+) and suppressor-inducer (CD4+CD45RA+) T cells in Japanese blue-collar workers
    Kawakami, N
    Tanigawa, T
    Araki, S
    Nakata, A
    Sakurai, S
    Yokoyama, K
    Morita, Y
    PSYCHOTHERAPY AND PSYCHOSOMATICS, 1997, 66 (04) : 192 - 198
  • [7] NEONATAL CD4+CD45RA+ T-CELLS - PRECURSORS OF ADULT CD4+CD45RA+ T-CELLS
    HASSAN, J
    REEN, DJ
    RESEARCH IN IMMUNOLOGY, 1993, 144 (02): : 87 - 92
  • [8] A COMPLEX DYSREGULATION OF CD4+CD45RA+ (NAIVE) AND CD4+CD45R0+ (MEMORY) T-CELLS IN ATOPIC PATIENTS
    NASERT, S
    ELLENSOHN, P
    KOETTGEN, E
    TAUBER, R
    WAHN, U
    RENZ, H
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 93 (01) : 187 - 187
  • [9] CD4+CD45RA+ AND CD4+CD45RA-T-CELL SUBSETS IN MAN MAINTAIN DISTINCT FUNCTION AND CD45RA EXPRESSION PERSISTS ON A SUBPOPULATION OF CD45RA+ CELLS AFTER ACTIVATION WITH CON A
    ROTHSTEIN, DM
    SOHEN, S
    DALEY, JF
    SCHLOSSMAN, SF
    MORIMOTO, C
    CELLULAR IMMUNOLOGY, 1990, 129 (02) : 449 - 467
  • [10] CONCOMITANT AUGMENTATION OF CD4+CD29+ HELPER INDUCER AND DIMINUTION OF CD4+CD45RA+ SUPPRESSOR INDUCER SUBSET IN PATIENTS INFECTED WITH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I OR TYPE-II
    LAL, RB
    RUDOLPH, DL
    SCHMID, DS
    LAIRMORE, MD
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1992, 87 (02): : 293 - 297
12345