A PROTEIN HISTIDINE KINASE INDUCED IN RAT-LIVER BY PEROXISOME PROLIFERATORS - INVITRO ACTIVATION BY RAS PROTEIN AND GUANINE-NUCLEOTIDES

被引：31
作者：
MOTOJIMA, K
GOTO, S
机构：
[1] Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba
来源：
FEBS LETTERS | 1993年 / 319卷 / 1-2期
关键词：
HISTIDINE KINASE; PEROXISOME PROLIFERATOR; RAS PROTEIN; SIGNAL TRANSDUCTION; RAT LIVER;
D O I：
10.1016/0014-5793(93)80040-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel protein kinase is induced in rat liver plasma membrane by the administration of peroxisome proliferators. A 36 kDa protein (P36) on the membrane was rapidly phosphorylated in vitro by the kinase and the phosphorylated amino acid was identified as phosphohistidine. Histidine phosphorylation of P36 was activated in vitro by recombinant Ras protein and GTP; both decreased Michaelis constant (K(m)) for ATP from 1.25 to 0.25 muM. The novel histidine kinase, products of which have been overlooked due to their acid lability, may participate in cellular signaling and peroxisome proliferators may perturb the pathway.
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页码：75 / 79
页数：5
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