PREPARATION OF 5-(PYRROLYLCARBONYL)-PYRIMIDINES AND 5-(IMIDAZOLYLCARBONYL)-PYRIMIDINES

被引：21
|
作者：
GAARE, K
REPSTAD, T
BENNECHE, T
UNDHEIM, K
机构：
来源：
ACTA CHEMICA SCANDINAVICA | 1993年 / 47卷 / 01期
关键词：
D O I：
10.3891/acta.chem.scand.47-0057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
2-Methylthio-5-(pyrrolylcarbonyl)-pyrimidines have been prepared from 1-methyl-2-tributylstannylpyrrole and 2-methylthiopyrimidine-5-carbonyl chloride by Pd-catalysis. Triphenylarsine was superior to triphenylphosphine as a ligand in the reaction. The reaction with phosphine ligands proceeded well when the polarization of the reactants was reversed as in the reaction between pyrrolecarbonyl chlorides and 2-methylthio-5-tributylstannylpyrimidine. 1-Methyl-5-tributylstannylimidazole has been prepared in a one-pot reaction from 1-methylimidazole in 91 % yield.
引用
收藏
页码：57 / 62
页数：6
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