EFFECT OF PYRIMETHAMINE RESISTANCE ON SPOROGONY IN A PLASMODIUM-BERGHEI ANOPHELES-STEPHENSI MODEL

被引：25
作者：
SHINONDO, CJ
LANNERS, HN
LOWRIE, RC
WISER, MF
机构：
[1] TULANE UNIV, SCH PUBL HLTH & TROP MED, DEPT TROP MED, NEW ORLEANS, LA 70112 USA
[2] TULANE REG PRIMATE RES CTR, COVINGTON, LA 70433 USA
来源：
EXPERIMENTAL PARASITOLOGY | 1994年 / 78卷 / 02期
关键词：
PLASMODIUM BERGHEI; ANOPHELES STEPHENSI; PYRIMETHAMINE; DRUG RESISTANCE; SPOROGONY; MALARIA; DIHYDROFOLATE REDUCTASE; PYRIMETHAMINE-RESISTANT LINE OF PLASMODIUM BERGHEI ANKA (PYR(R)); PYRIMETHAMINE-SENSITIVE LINE OF PLASMODIUM BERGHEI ANKA (PYR(S));
D O I：
10.1006/expr.1994.1019
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
A pyrimethamine-resistant line of Plasmodium berghei was derived by treating infected mice with high doses of pyrimethamine and selecting for recrudescence. This resistant line was compared with the parental pyrimethamine-sensitive line in order to ascertain whether drug resistance is associated with a biological advantage. Overall, the pyrimethamine-resistant line is quite similar to the sensitive line, except that it proceeds through sporogonic development more slowly than the pyrimethamine-sensitive parental line. However, under pyrimethamine pressure the sensitive line is unable to undergo the sporogonic cycle, whereas the resistant line is unaffected. These results indicate that the transmission of pyrimethamine resistance in this model is favored only under conditions of drug pressure. (C) 1994 Academic Press, Inc.
引用
收藏
页码：194 / 202
页数：9
相关论文
共 28 条
[1]  
Burgess R. W., 1959, Bulletin of the World Health Organization, V20, P37
[2]  
Clyde D. F., 1959, Transactions of the Royal Society of Tropical Medicine and Hygiene London, V53, P170, DOI 10.1016/0035-9203(59)90067-7
[3]  
Clyde David F, 1967, MALARIA TANZANIA
[4]  
COOSEMANS MH, 1985, ANN SOC BELG MED TR, V65, P115
[5]   AMINO-ACID CHANGES LINKED TO PYRIMETHAMINE RESISTANCE IN THE DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE OF PLASMODIUM-FALCIPARUM [J].
COWMAN, AF ;
MORRY, MJ ;
BIGGS, BA ;
CROSS, GAM ;
FOOTE, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9109-9113
[6]   ALTERED DIHYDROFOLATE REDUCTASE ASSOCIATED WITH A PYRIMETHAMINE-RESISTANT PLASMODIUM-BERGHEI-BERGHEI PRODUCED IN A SINGLE STEP [J].
DIGGENS, SM ;
GUTTERIDGE, WE ;
TRIGG, PI .
NATURE, 1970, 228 (5271) :579-+
[7]  
GARRETT-JONES C, 1969, Bulletin of the World Health Organization, V40, P531
[8]  
GARRETTJONES C, 1964, NATURE, V204, P1176
[9]   DRUG SENSITIVITY AND ISOENZYME TYPE IN CLONED LINES OF PLASMODIUM-FALCIPARUM [J].
GRAVES, PM ;
CARTER, R ;
KEYSTONE, JS ;
SEELEY, DC .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (02) :212-219
[10]   THE EFFECTS OF CHLOROQUINE ON THE INFECTIVITY OF CHLOROQUINE-SENSITIVE AND CHLOROQUINE-RESISTANT POPULATIONS OF PLASMODIUM-YOELII-NIGERIENSIS TO MOSQUITOS [J].
ICHIMORI, K ;
CURTIS, CF ;
TARGETT, GAT .
PARASITOLOGY, 1990, 100 :377-381
123