EFFECTS OF BACLOFEN ON MEDIAL VESTIBULAR NUCLEUS NEURONS IN GUINEA-PIG BRAIN-STEM SLICES

被引：12

作者：

VIBERT, N ^{[1
]}

SERAFIN, M ^{[1
]}

VIDAL, PP ^{[1
]}

MUHLETHALER, M ^{[1
]}

机构：

[1] COLL FRANCE, LPPA, CNRS, UMR C9950, F-75270 PARIS 06, FRANCE

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 03期

关键词：

GAMMA-AMINOBUTYRIC ACID (GABA); GABA(B) RECEPTORS; VESTIBULOOCULAR REFLEX; INTRACELLULAR RECORDINGS;

D O I：

10.1016/0304-3940(94)11149-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using intracellular recordings of medial-vestibular nucleus neurones (MVNn) in guinea-pig brainstem slices, the effects of baclofen, a specific agonist of the metabotropic GABAB receptors, were tested on the three main types of MVNn (A, B and B + LTS MVNn) that were previously identified in this nucleus. Regardless of their type, almost all MVNn were hyperpolarized and inhibited by baclofen. These hyperpolarizing effects persisted following either the addition of tetrodotoxin (TTX) in the perfusion medium, or in the presence of a high Mg2+/low Ca2+ solution known to block synaptic transmission. These results demonstrate that all types of MVNn are endowed with postsynaptic GABA(B) receptors.

引用

页码：193 / 197

页数：5

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