INTERLEUKIN-10 PRODUCTION DURING SEPTICEMIA

被引：297

作者：

MARCHANT, A

DEVIERE, J

BYL, B

DEGROOTE, D

VINCENT, JL

GOLDMAN, M

机构：

[1] UNIV LIBRE BRUXELLES,HOP ERASME,DEPT IMMUNOL,B-1070 BRUSSELS,BELGIUM

[2] UNIV LIBRE BRUXELLES,HOP ERASME,DEPT GASTROENTEROL,B-1070 BRUSSELS,BELGIUM

[3] UNIV LIBRE BRUXELLES,HOP ERASME,DEPT INFECT DIS,B-1070 BRUSSELS,BELGIUM

[4] UNIV LIBRE BRUXELLES,HOP ERASME,INTENS CARE UNIT,B-1070 BRUSSELS,BELGIUM

[5] MEDGENIX GRP,DEPT RES & DEV,FLEURUS,BELGIUM

来源：

LANCET | 1994年 / 343卷 / 8899期

关键词：

D O I：

10.1016/S0140-6736(94)91584-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-10 is produced during incubation of human whole blood with bacterial lipopolysaccharide (LPS) and down-regulates tumour necrosis factor-alpha production in this in-vitro model of endotoxaemia. 39 out of 69 (57%) patients with gram-negative (n = 25) or gram-positive septicaemia (n = 44) had increased plasma interleukin-10 (range 12-2740 pg/mL), whereas interleukin-10 was undetectable in 29 out of 33 control patients without infection and in 20 healthy volunteers. Patients with septic shock (n = 21) had higher interleukin-10 (median 58 pg/mL) than septicaemic patients without shock (11 pg/mL, p<0.001). We conclude that interleukin-10 is produced during sepsis and might be involved in the control of the inflammatory response induced by bacterial products.

引用

页码：707 / 708

页数：2

共 8 条

[1] MACROPHAGE DEACTIVATION BY INTERLEUKIN-10 [J].