共 10 条
Recurrence of primary sclerosing cholangitis after liver transplantation - The Hungarian experience
被引:13
作者:

Gelley, Fanni
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机构:
Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Zadori, Gergely
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Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Gorog, Denes
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Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Kobori, Laszlo
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机构:
Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

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Gaman, Gyorgy
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机构:
Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Gerlei, Zsuzsanna
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机构:
Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Nagy, Peter
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机构:
Semmelweis Univ, Dept Pathol & Expt Canc Res 2, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Sarvary, Eniko
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h-index: 0
机构:
Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary

Nemes, Balazs
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机构:
Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary
机构:
[1] Semmelweis Univ, Dept Transplantat & Surg, Budapest, Hungary
[2] Semmelweis Univ, Dept Pathol & Expt Canc Res 2, Budapest, Hungary
关键词:
disease recurrence;
inflammatory bowel disease;
liver transplantation;
primary sclerosing cholangitis;
D O I:
10.1556/IMAS.6.2014.1.2
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Introduction: Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects longterm graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary. Patients and Methods: We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%). Results: Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had significantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining five patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis. Conclusions: Recurrent PSC signifi cantly affects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective effect against rPSC.
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页码:16 / 18
页数:3
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h-index: 0
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