ADULT ACUTE LYMPHOBLASTIC-LEUKEMIA - RESULTS OF AN AGGRESSIVE REGIMEN IN INDIA

被引：5

作者：

RAJE, N ^{[1
]}

PAI, S ^{[1
]}

VAIDYA, S ^{[1
]}

GOPAL, R ^{[1
]}

PARIKH, P ^{[1
]}

SAIKIA, T ^{[1
]}

PAI, V ^{[1
]}

NADKARNI, K ^{[1
]}

ADVANI, IMS ^{[1
]}

机构：

[1] TATA MEM HOSP,DEPT MED ONCOL,BOMBAY 400012,INDIA

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 14卷 / 3-4期

关键词：

ADULT ALL; AGGRESSIVE CHEMOTHERAPY; SURVIVAL;

D O I：

10.3109/10428199409049680

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 42 adults with acute lymphoblastic leukemia were treated with an aggressive induction/consolidation chemotherapy (MCP-841) between June 1986 and December 1991. 32 patients (76.19%) achieved complete remission at the end of induction. There were 9 induction deaths, 6 of them due to infection. All patients received cranial irradiation in the dose of 20 Gy and intrathecal methotrexate for CNS prophylaxis. Twelve patients relapsed, 10 in the bone marrow, one case had isolated CNS relapse and the other relapsed in the bone marrow and CNS. The actuarial overall survival of all patients at the end of 5 years was 41.94%. Patient characteristics including age, sex, FAB morphology, phenotype, WBC count, platelet count and LDH did not influence survival significantly.

引用

页码：285 / 290

页数：6

共 26 条

[1]

Jones B., Holland J.F., Glidewell O., Jacquillat C., Weill M., Optimal use of L-asparaginase in acute lymphoblastic leukemia, Med. Pediatr. Oncol., 3, (1977)

[2]

Ortega J.A., Nesbit M.E., Donaldson M.H., Hittle R.E., Weiner J., Karon M., Hammond D., L-asparaginase, vincristine and prednisolone for induction of first remission in acute lymphoblastic leukemia, Cancer Res., 37, (1977)

[3]

Woodruff R., The management of adult acute lymphoblastic leukemia, Cancer Treat. Rev., 5, (1978)

[4]

Chessels J.M., Acute lymphoblastic leukemia, Semin. Hematol., 19, (1982)

[5]

Gee T.S., Haghbin M., Dowling M.D., Cunningham J., Middleman M.P., Clarkson B.D., Acute lymphoblastic leukemia in adults and children-differences in response with similar therapeutic regimens, Cancer, 37, (1976)

[6]

Mauer A.M., Adult and childhood acute lymphocytic leukemia: Are they different diseases?, Am. J. Hematol., 42, 1, pp. 127-131, (1993)

[7]

Mayer R.J., Acute Lymphoblastic leukemia in adults, Ann. Intern. Med., 101, (1984)

[8]

Jacobs A.D., Gale R.P., Recent advances in the biology and treatment of acute lymphoblastic leukemia in adults, N. Engl. J. Med., 319, (1984)

[9]

Linker C.A., Levitt L.J., O'Donell M., Ries C.A., Link M.P., Forman S.J., Farbstein H.J., Improved results of treatment of adult acute lymphoblastic leukemia, Blood, 69, pp. 1242-1248, (1987)

[10]

Larson R.A., Bums C.P., Dodge R.K., George S.C., A 5 drug regimen with intensive consolidation for adult acute lymphoblastic leukemia (ALL): Cancer and leukemia group B (Meeting Abstract), Proc. Ann. Meet. Am. Soc. Clin. Oncol., 11, A, (1992)

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