linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer

被引：18

作者：

Abdul-Rahman, Ubaidat ^{[1
]}

Gyorffy, Balazs ^{[2
,3
]}

Adams, Brian D. ^{[1
,4
]}

机构：

[1] SUNY Albany, RNA Inst, 1400 Washington Ave, Albany, NY 12222 USA

[2] Hungarian Acad Sci, MTA TTK Lendulet Canc Biomarker Res Grp, Budapest, Hungary

[3] Semmelweis Univ, Dept Pediat 2, Budapest, Hungary

[4] Yale Univ, Sch Med, Invest Med Program, 333 Cedar St, New Haven, CT 06520 USA

来源：

TRANSCRIPTION-AUSTIN | 2018年 / 9卷 / 01期

关键词：

breast cancer; ERRLR01; estrogen signaling; hormone-regulation; lncRNA; survival outcomes;

D O I：

10.1080/21541264.2017.1329684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ER alpha(-) tumors correlated with negative overall survival, while in ER alpha(+) tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including "epithelial development" and "cellular differentiation." These data suggest ERRLR01 operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.

引用

页码：17 / 29

页数：13

共 61 条

[1] miR-519 suppresses tumor growth by reducing HuR levels [J].

Abdelmohsen, Kotb ;

Kim, Mihee M. ;

Srikantan, Subramanya ;

Mercken, Evi M. ;

Brennan, Sarah E. ;

Wilson, Gerald M. ;

de Cabo, Rafael ;

Gorospe, Myriam .

CELL CYCLE, 2010, 9 (07) :1354-1359

[2] miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels [J].

Abdelmohsen, Kotb ;

Srikantan, Subramanya ;

Kuwano, Yuki ;

Gorospe, Myriam .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20297-20302

[3] miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer [J].

Adams, Brian D. ;

Wali, Vikram B. ;

Cheng, Christopher J. ;

Inukai, Sachi ;

Booth, Carmen J. ;

Agarwal, Seema ;

Rimm, David L. ;

Gyorffy, Balazs ;

Santarpia, Libero ;

Pusztai, Lajos ;

Saltzman, W. Mark ;

Slack, Frank J. .

CANCER RESEARCH, 2016, 76 (04) :927-939

[4] Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss [J].

Arun, Gayatri ;

Diermeier, Sarah ;

Akerman, Martin ;

Chang, Kung-Chi ;

Wilkinson, J. Erby ;

Hearn, Stephen ;

Kim, Youngsoo ;

MacLeod, A. Robert ;

Krainer, Adrian R. ;

Norton, Larry ;

Brogi, Edi ;

Egeblad, Mikala ;

Spector, David L. .

GENES & DEVELOPMENT, 2016, 30 (01) :34-51

[5]

Bhan A, 2016, METHODS MOL BIOL, V1366, P395, DOI 10.1007/978-1-4939-3127-9_31

[6] Long noncoding RNAs and the genetics of cancer [J].

Cheetham, S. W. ;

Gruhl, F. ;

Mattick, J. S. ;

Dinger, M. E. .

BRITISH JOURNAL OF CANCER, 2013, 108 (12) :2419-2425

[7]

Cotterill S., CANC GENET

[8] Regulatory networks defining EMT during cancer initiation and progression [J].

De Craene, Bram ;

Berx, Geert .

NATURE REVIEWS CANCER, 2013, 13 (02) :97-110

[9] CTCF Binding Polarity Determines Chromatin Looping [J].

de Wit, Elzo ;

Vos, Erica S. M. ;

Holwerda, Sjoerd J. B. ;

Valdes-Quezada, Christian ;

Verstegen, Marjon J. A. M. ;

Teunissen, Hans ;

Splinter, Erik ;

Wijchers, Patrick J. ;

Krijger, Peter H. L. ;

de laat, Wouter .

MOLECULAR CELL, 2015, 60 (04) :676-684

[10] LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint [J].

Dimitrova, Nadya ;

Zamudio, Jesse R. ;

Jong, Robyn M. ;

Soukup, Dylan ;

Resnick, Rebecca ;

Sarma, Kavitha ;

Ward, Amanda J. ;

Raj, Arjun ;

Lee, Jeannie T. ;

Sharp, Phillip A. ;

Jacks, Tyler .

MOLECULAR CELL, 2014, 54 (05) :777-790

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