CYTOGENETIC DAMAGE IN MARROW-CELLS OF MICE AFTER INJECTIONS OF YTTRIUM-90-LABELED MONOCLONAL-ANTIBODY

Chromosome aberrations, micronuclei and sister-chromatid exchanges were quantified in marrow cells of athymic nude and B6C3F1 mice at various times up to 14 days after injection of Y-90-labeled monoclonal antibody CO17-1A. Aberrations, predominantly of the chromatid type, were sharply elevated at 24 h post-injection then declined in a curvilinear fashion over the 14 days. Micronucleus numbers among polychromatic erythrocytes peaked 3-4 days after treatment, then declined exponentially but remained at higher than expected levels. Sister-chromatid exchanges were roughly double the control rate with no apparent relation to post-treatment time.