The Role of Inflammation in the Pathogenesis of Colorectal Cancer

被引：70

作者：

McConnell, Beth B. ^{[1
]}

Yang, Vincent W. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Digest Dis, 201 Whitehead Res Bldg,615 Michael St, Atlanta, GA 30322 USA

来源：

CURRENT COLORECTAL CANCER REPORTS | 2009年 / 5卷 / 02期

关键词：

D O I：

10.1007/s11888-009-0011-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.

引用

页码：69 / 74

页数：6

共 43 条

[1] Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study [J].

Arber, N ;

Kuwada, S ;

Leshno, M ;

Sjodahl, R ;

Hultcrantz, R ;

Rex, D .

GUT, 2006, 55 (03) :367-373

[2]

Attiga FA, 2000, CANCER RES, V60, P4629

[3] TNF-α in promotion and progression of cancer [J].

Balkwill, Frances .

CANCER AND METASTASIS REVIEWS, 2006, 25 (03) :409-416

[4] Celecoxib for the prevention of sporadic colorectal adenomas [J].

Bertagnolli, Monica M. ;

Eagle, Craig J. ;

Zauber, Ann G. ;

Redston, Mark ;

Solomon, Scott D. ;

Kim, KyungMann ;

Tang, Jie ;

Rosenstein, Rebecca B. ;

Wittes, Janet ;

Corle, Donald ;

Hess, Timothy M. ;

Woloj, G. Mabel ;

Boisserie, Frederic ;

Anderson, William F. ;

Viner, Jaye L. ;

Bagheri, Donya ;

Burn, John ;

Chung, Daniel C. ;

Dewar, Thomas ;

Foley, T. Raymond ;

Hoffman, Neville ;

Macrae, Finlay ;

Pruitt, Ronald E. ;

Saltzman, John R. ;

Salzberg, Bruce ;

Sylwestrowicz, Thomas ;

Gordon, Gary B. ;

Hawk, Ernest T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :873-884

[5]

Burstein E, 2008, J CLIN INVEST, V118, P464, DOI [10.1172/JC134831, 10.1172/JCI34831]

[6] Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease [J].

Cario, E ;

Podolsky, DK .

INFECTION AND IMMUNITY, 2000, 68 (12) :7010-7017

[7] UP-REGULATION OF CYCLOOXYGENASE-2 GENE-EXPRESSION IN HUMAN COLORECTAL ADENOMAS AND ADENOCARCINOMAS [J].

EBERHART, CE ;

COFFEY, RJ ;

RADHIKA, A ;

GIARDIELLO, FM ;

FERRENBACH, S ;

DUBOIS, RN .

GASTROENTEROLOGY, 1994, 107 (04) :1183-1188

[8] Polymorphisms in Toll-like receptor genes and risk of cancer [J].

El-Omar, E. M. ;

Ng, M. T. ;

Hold, G. L. .

ONCOGENE, 2008, 27 (02) :244-252

[9] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease [J].

Fisher, Sheila A. ;

Tremelling, Mark ;

Anderson, Carl A. ;

Gwilliam, Rhian ;

Bumpstead, Suzannah ;

Prescott, Natalie J. ;

Nimmo, Elaine R. ;

Massey, Dunecan ;

Berzuini, Carlo ;

Johnson, Christopher ;

Barrett, Jeffrey C. ;

Cummings, Fraser R. ;

Drummond, Hazel ;

Lees, Charlie W. ;

Onnie, Clive M. ;

Hanson, Catherine E. ;

Blaszczyk, Katarzyna ;

Inouye, Mike ;

Ewels, Philip ;

Ravindrarajah, Radhi ;

Keniry, Andrew ;

Hunt, Sarah ;

Carter, Martyn ;

Watkins, Nick ;

Ouwehand, Willem ;

Lewis, Cathryn M. ;

Cardon, Lon ;

Lobo, Alan ;

Forbes, Alastair ;

Sanderson, Jeremy ;

Jewell, Derek P. ;

Mansfield, John C. ;

Deloukas, Panos ;

Mathew, Christopher G. ;

Parkes, Miles ;

Satsangi, Jack .

NATURE GENETICS, 2008, 40 (06) :710-712

[10] Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility [J].

Franke, Andre ;

Balschun, Tobias ;

Karlsen, Tom H. ;

Sventoraityte, Jurgita ;

Nikolaus, Susanna ;

Mayr, Gabriele ;

Domingues, Francisco S. ;

Albrecht, Mario ;

Nothnagel, Michael ;

Ellinghaus, David ;

Sina, Christian ;

Onnie, Clive M. ;

Weersma, Rinse K. ;

Stokkers, Pieter C. F. ;

Wijmenga, Cisca ;

Gazouli, Maria ;

Strachan, David ;

McArdle, Wendy L. ;

Vermeire, Severine ;

Rutgeerts, Paul ;

Rosenstiel, Philip ;

Krawczak, Michael ;

Vatn, Morten H. ;

Mathew, Christopher G. ;

Schreiber, Stefan .

NATURE GENETICS, 2008, 40 (11) :1319-1323

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