QUANTITATION OF CEFACLOR IN PHARMACEUTICAL DOSAGE FORMS USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：4

作者：

MATHEW, M ^{[1
]}

DASGUPTA, V ^{[1
]}

BETHEA, C ^{[1
]}

机构：

[1] BEN TAUB GEN HOSP,HOUSTON,TX 77030

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 14期

关键词：

D O I：

10.3109/03639049309050163

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stability-indicating high-performance liquid chromatography for the quantitation of cefaclor in pharmaceutical dosage forms has been developed. The method is accurate and precise with a percent relative standard deviation of 1.2 based on 5 readings. A number of inactive ingredients present in the capsules and suspensions did not interfere with the assay procedure. The extraction procedure from the dosage forms is very simple. The recovery from the synthetic mixtures was quantitative. The capsules which had expired 3 years ago lost only 3% of the potency. The drug appears to be very sensitive to strong acids or bases since a 5 minute boiling caused 100% degradation of drug in both the solutions.

引用

页码：1723 / 1729

页数：7