CHROMOSOME-ABNORMALITIES IN PERIPHERAL LYMPHOCYTES FROM PATIENTS WITH PROGRESSIVE SYSTEMIC-SCLEROSIS

被引：0
作者：
TAKEUCHI, F
NAKANO, K
YAMADA, H
KOSUGE, E
HIRAI, M
MAEDA, H
MOROI, Y
机构：
[1] UNIV TOKYO,FAC SCI,DEPT ANTHROPOL,TOKYO 113,JAPAN
[2] SAITAMA MED CTR,SAITAMA MED SCH,BLOOD TRANSFUS SERV,KAWAGOE,SAITAMA 350,JAPAN
来源：
RHEUMATOLOGY INTERNATIONAL | 1993年 / 12卷 / 06期
关键词：
PSS; CHROMOSOME; D-PHENICILLAMINE; PREDNISOLONE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chromosomal abnormalities in cultured peripheral lymphocytes from 14 progressive systemic sclerosis (PSS) patients and 15 normal subjects were examined. No increase was observed in the frequency of chromosome aberrations in PSS patients who had not received any medical treatment. Those who had received medication showed an increased frequency of dicentrics (0.3%) although the frequency was not significantly higher than that for normal subjects. It is not clear, however, whether the increase was due to the hypersensitivity of PSS patients to agents used for therapeutic purposes.
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页码：243 / 246
页数：4
相关论文
共 19 条
  • [1] CLASTOGENIC INOSINE NUCLEOTIDE AS COMPONENTS OF THE CHROMOSOME BREAKAGE FACTOR IN SCLERODERMA PATIENTS
    AUCLAIR, C
    GOUYETTE, A
    LEVY, A
    EMERIT, I
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 278 (01) : 238 - 244
  • [2] BEIN G, 1992, TISSUE ANTIGENS, V39, P86
  • [3] EMERIT I, 1971, REV EUR ETUD CL BIOL, V16, P684
  • [4] EMERIT I, 1976, J LAB CLIN MED, V88, P81
  • [5] EMERIT I, 1980, Z RHEUMATOL, V39, P84
  • [6] HIRAI M, 1986, JPN J EXP MED, V56, P285
  • [7] MAEDA H, 1980, TISSUE ANTIGENS, V15, P173
  • [8] MOROI Y, 1982, 1981 MIN HLTH WELF S, P66
  • [9] SISTER CHROMATID EXCHANGE FREQUENCIES IN PATIENTS WITH SCLERODERMA AND THEIR RELATIVES
    PALMER, RG
    PEREIRA, RS
    DORE, CJ
    DENMAN, AM
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 1986, 45 (05) : 409 - 411
  • [10] PAN SF, 1975, J LAB CLIN MED, V86, P300
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