A COAT SUBUNIT OF GOLGI-DERIVED NON-CLATHRIN-COATED VESICLES WITH HOMOLOGY TO THE CLATHRIN-COATED VESICLE COAT PROTEIN BETA-ADAPTIN

被引：312
作者：
SERAFINI, T
STENBECK, G
BRECHT, A
LOTTSPEICH, F
ORCI, L
ROTHMAN, JE
WIELAND, FT
机构：
[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544
[2] UNIV HEIDELBERG,INST BIOCHEM 1,W-6900 HEIDELBERG,GERMANY
[3] MAX PLANCK INST BIOCHEM,GENZENTRUM,W-8033 MARTINSRIED,GERMANY
[4] UNIV GENEVA,DEPT MORPHOL,CH-1211 GENEVA 4,SWITZERLAND
来源：
NATURE | 1991年 / 349卷 / 6306期
关键词：
D O I：
10.1038/349215a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Four high-molecular-weight proteins form the main subunits of the coat of Golgi-derived (non-clathrin) coated vesicles. One of these coat proteins, beta-COP, is identical to a Golgi-associated protein of relative mass 110,000 (110K) that shares homology with the adaptin proteins of clathrin-coated vesicles. This connection, and the comparable molecular weights of the coat proteins of Golgi-derived and clathrin-coated vesicles, indicates that they may be structurally related. The identification of beta-COP as the 110K protein explains the blocking of secretion by the drug brefeldin A.
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页码：214 / 220
页数：7
相关论文
共 51 条
[1]  
AHLE S, 1989, J BIOL CHEM, V264, P20089
[2]   STRUCTURAL RELATIONSHIPS BETWEEN CLATHRIN ASSEMBLY PROTEINS FROM THE GOLGI AND THE PLASMA-MEMBRANE [J].
AHLE, S ;
MANN, A ;
EICHELSBACHER, U ;
UNGEWICKELL, E .
EMBO JOURNAL, 1988, 7 (04) :919-929
[3]   A MICROTUBULE-BINDING PROTEIN ASSOCIATED WITH MEMBRANES OF THE GOLGI-APPARATUS [J].
ALLAN, VJ ;
KREIS, TE .
JOURNAL OF CELL BIOLOGY, 1986, 103 (06) :2229-2239
[4]   RECONSTITUTION OF THE TRANSPORT OF PROTEIN BETWEEN SUCCESSIVE COMPARTMENTS OF THE GOLGI MEASURED BY THE COUPLED INCORPORATION OF N-ACETYLGLUCOSAMINE [J].
BALCH, WE ;
DUNPHY, WG ;
BRAELL, WA ;
ROTHMAN, JE .
CELL, 1984, 39 (02) :405-416
[5]   CHARACTERIZATION OF PROTEIN-TRANSPORT BETWEEN SUCCESSIVE COMPARTMENTS OF THE GOLGI-APPARATUS - ASYMMETRIC PROPERTIES OF DONOR AND ACCEPTOR ACTIVITIES IN A CELL-FREE SYSTEM [J].
BALCH, WE ;
ROTHMAN, JE .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 240 (01) :413-425
[6]   SEQUENTIAL INTERMEDIATES IN THE PATHWAY OF INTERCOMPARTMENTAL TRANSPORT IN A CELL-FREE SYSTEM [J].
BALCH, WE ;
GLICK, BS ;
ROTHMAN, JE .
CELL, 1984, 39 (03) :525-536
[7]  
BALCH WE, 1983, METHOD ENZYMOL, V98, P37
[8]   ASSAY OF PROTEINS IN PRESENCE OF INTERFERING MATERIALS [J].
BENSADOUN, A ;
WEINSTEIN, D .
ANALYTICAL BIOCHEMISTRY, 1976, 70 (01) :241-250
[9]   PURIFICATION OF AN N-ETHYLMALEIMIDE-SENSITIVE PROTEIN CATALYZING VESICULAR TRANSPORT [J].
BLOCK, MR ;
GLICK, BS ;
WILCOX, CA ;
WIELAND, FT ;
ROTHMAN, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :7852-7856
[10]   BREFELDIN-A REDISTRIBUTES RESIDENT AND ITINERANT GOLGI PROTEINS TO THE ENDOPLASMIC-RETICULUM [J].
DOMS, RW ;
RUSS, G ;
YEWDELL, JW .
JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :61-72
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