USE OF PLASMA PHARMACOKINETICS TO PREDICT AND PREVENT METHOTREXATE TOXICITY

被引：384
作者：
STOLLER, RG
HANDE, KR
JACOBS, SA
ROSENBERG, SA
CHABNER, BA
机构：
[1] NIH, BETHESDA, MD 20014 USA
[2] NCI, CLIN PHARMACOL BRANCH, BETHESDA, MD 20014 USA
[3] NCI, SURG BRANCH, BETHESDA, MD 20014 USA
[4] NCI, MED BRANCH, BETHESDA, MD 20014 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 1977年 / 297卷 / 12期
关键词：
D O I：
10.1056/NEJM197709222971203
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：630 / 634
页数：5
相关论文
共 17 条
[1]  
BERTINO J R, 1964, Methods Med Res, V10, P297
[2]   THRESHOLD METHOTREXATE CONCENTRATION FOR IN-VIVO INHIBITION OF DNA-SYNTHESIS IN NORMAL AND TUMOROUS TARGET TISSUES [J].
CHABNER, BA ;
YOUNG, RC .
JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (08) :1804-1811
[3]   ENZYMATIC CLEAVAGE OF METHOTREXATE PROVIDES A METHOD FOR PREVENTION OF DRUG TOXICITY [J].
CHABNER, BA ;
BERTINO, JR ;
JOHNS, DG .
NATURE, 1972, 239 (5372) :395-&
[4]  
DJERASSI I, 1967, CANCER, V20, P233, DOI 10.1002/1097-0142(1967)20:2<233::AID-CNCR2820200209>3.0.CO
[5]  
2-8
[6]  
DJERASSI I, 1977, CANCER TREAT REP, V61, P751
[7]  
DJERASSI I, 1972, CANCER, V30, P22, DOI 10.1002/1097-0142(197207)30:1<22::AID-CNCR2820300105>3.0.CO
[8]  
2-B
[9]   7-HYDROXYMETHOTREXATE AS A URINARY METABOLITE IN HUMAN SUBJECTS AND RHESUS-MONKEYS RECEIVING HIGH DOSE METHOTREXATE [J].
JACOBS, SA ;
STOLLER, RG ;
CHABNER, BA ;
JOHNS, DG .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (02) :534-538
[10]  
JAFFE N, 1972, CANCER-AM CANCER SOC, V30, P1627, DOI 10.1002/1097-0142(197212)30:6<1627::AID-CNCR2820300631>3.0.CO
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