Preclinical HER-2 vaccines: from rodent to human HER-2

被引:6
作者
Lollini, Pier-Luigi [1 ]
De Giovanni, Carla [1 ]
Nanni, Patrizia [1 ]
机构
[1] Univ Bologna, Alma Mater Studiorum, Lab Immunol & Biol Metastases, Dept Expt Diagnost & Specialty Med, Viale Filopanti 22, I-40126 Bologna, Italy
来源
FRONTIERS IN ONCOLOGY | 2013年 / 3卷
关键词
HER-2; tumor immunology; oncoantigens; mouse models; metastasis; immunodeficient mice;
D O I
10.3389/fonc.2013.00151
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Effective prevention of human cancer with vaccines against viruses, such as HBV and HPV, raises the question whether also non-virus related tumors could be prevented with immunological means. Studies in HER-2-transgenic mice showed that powerful anti-HER-2 vaccines, could almost completely prevent the onset of mammary carcinoma. Protective immune responses were orchestrated by T cells and their cytokines, and effected by antibodies against HER-2 gene product p185. Analogous findings were reported in a variety of other cancer immunoprevention systems, thus leading to the definition of oncoantigens, optimal target antigens that are causally involved in carcinogenesis and cancer progression. Prophylactic HER-2 vaccines were also effective in preventing metastasis outgrowth, indicating that concepts and approaches developed for cancer immunoprevention could prove fruitful in cancer immunotherapy as well. The availability of cancer-prone mice carrying a human HER-2 transgene is now fostering the design of novel vaccines against human p185. A further bridge toward human cancer was recently provided by novel immunodeficient models, like Rag2(-/-); 112rg(-/-) mice, which are permissive for metastatic spread of human HER-2+ cancer cells and can be engrafted with a functional human immune system, allowing for the first time the study of vaccines against oncoantigens to elicit human immune responses against human cancer cells in vivo.
引用
收藏
页数:7
相关论文
共 66 条
  • [1] ALLIONE A, 1994, CANCER RES, V54, P6022
  • [2] Genetic immunization against neu/erbB2 transgenic breast cancer
    Amici, A
    Venanzi, FM
    Concetti, A
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 1998, 47 (04) : 183 - 190
  • [3] Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma
    Astolfi, A
    Landuzzi, L
    Nicoletti, G
    De Giovanni, C
    Croci, S
    Palladini, A
    Ferrini, S
    Iezzi, M
    Musiani, P
    Cavallo, F
    Forni, G
    Nanni, P
    Lollini, PL
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (04) : 1205 - 1216
  • [4] Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of HER-2/neu transgenic mice
    Boggio, K
    Nicoletti, G
    Di Carlo, E
    Cavallo, F
    Landuzzi, L
    Melani, C
    Giovarelli, M
    Rossi, I
    Nanni, P
    De Giovanni, C
    Bouchard, P
    Wolf, S
    Modesti, A
    Musiani, P
    Lollini, PL
    Colombo, MP
    Forni, G
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (03) : 589 - 596
  • [5] Humanized mouse models to study human diseases
    Brehm, Michael A.
    Shultz, Leonard D.
    Greiner, Dale L.
    [J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2010, 17 (02) : 120 - 125
  • [6] Role of exon-16-deleted HER2 in breast carcinomas
    Castiglioni, F
    Tagliabue, E
    Campiglio, M
    Pupa, SM
    Balsari, A
    Ménard, S
    [J]. ENDOCRINE-RELATED CANCER, 2006, 13 (01) : 221 - 232
  • [7] 2011: the immune hallmarks of cancer
    Cavallo, Federica
    De Giovanni, Carla
    Nanni, Patrizia
    Forni, Guido
    Lollini, Pier-Luigi
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (03) : 319 - 326
  • [8] Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study
    Chang, Mei-Hwei
    You, San-Lin
    Chen, Chien-Jen
    Liu, Chun-Jen
    Lee, Chuan-Mo
    Lin, Shi-Ming
    Chu, Heng-Cheng
    Wu, Tzee-Chung
    Yang, Sheng-Shun
    Kuo, Hsu-Sung
    Chen, Ding-Shinn
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (19): : 1348 - 1355
  • [9] The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research
    Cheever, Martin A.
    Allison, James P.
    Ferris, Andrea S.
    Finn, Olivera J.
    Hastings, Benjamin M.
    Hecht, Toby T.
    Mellman, Ira
    Prindiville, Sheila A.
    Viner, Jaye L.
    Weiner, Louis M.
    Matrisian, Lynn M.
    [J]. CLINICAL CANCER RESEARCH, 2009, 15 (17) : 5323 - 5337
  • [10] Optimized DNA vaccines to specifically induce therapeutic CD8 T cell responses against autochthonous breast tumors
    Cho, Hyun-Il
    Niu, Guilian
    Bradley, Norma
    Celis, Esteban
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (11) : 1695 - 1703