Exercise and Early-Onset Alzheimer's Disease: Theoretical Considerations

被引：12
作者：
Hooghiemstra, Astrid M. [1 ,2 ]
Eggermont, Laura H. P. [1 ]
Scheltens, Philip [2 ]
van der Flier, Wiesje M. [2 ,3 ]
Scherder, Erik J. A. [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2012年 / 2卷 / 01期
关键词：
Dementia; Early-onset Alzheimer's disease; Early-onset dementia; Intervention; Physical activity; Presenile dementia;
D O I：
10.1159/000335493
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background/Aims: Although studies show a negative relationship between physical activity and the risk for cognitive impairment and late-onset Alzheimer's disease, studies concerning early-onset Alzheimer's disease (EOAD) are lacking. This review aims to justify the value of exercise interventions in EOAD by providing theoretical considerations that include neurobiological processes. Methods: A literature search on key words related to early-onset dementia, exercise, imaging, neurobiological mechanisms, and cognitive reserve was performed. Results/Conclusion: Brain regions and neurobiological processes contributing to the positive effects of exercise are affected in EOAD and, thus, provide theoretical support for exercise interventions in EOAD. Finally, we present the design of a randomized controlled trial currently being conducted in early-onset dementia patients. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：132 / 145
页数：14
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