Exercise and Early-Onset Alzheimer's Disease: Theoretical Considerations

被引：11

作者：

Hooghiemstra, Astrid M. ^{[1
,2
]}

Eggermont, Laura H. P. ^{[1
]}

Scheltens, Philip ^{[2
]}

van der Flier, Wiesje M. ^{[2
,3
]}

Scherder, Erik J. A. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2012年 / 2卷 / 01期

关键词：

Dementia; Early-onset Alzheimer's disease; Early-onset dementia; Intervention; Physical activity; Presenile dementia;

D O I：

10.1159/000335493

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background/Aims: Although studies show a negative relationship between physical activity and the risk for cognitive impairment and late-onset Alzheimer's disease, studies concerning early-onset Alzheimer's disease (EOAD) are lacking. This review aims to justify the value of exercise interventions in EOAD by providing theoretical considerations that include neurobiological processes. Methods: A literature search on key words related to early-onset dementia, exercise, imaging, neurobiological mechanisms, and cognitive reserve was performed. Results/Conclusion: Brain regions and neurobiological processes contributing to the positive effects of exercise are affected in EOAD and, thus, provide theoretical support for exercise interventions in EOAD. Finally, we present the design of a randomized controlled trial currently being conducted in early-onset dementia patients. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：132 / 145

页数：14

共 118 条

[1] Prolonged Voluntary Wheel-Running Stimulates Neural Precursors in the Hippocampus and Forebrain of Adult CD1 Mice [J].