EMERGENCE OF BACTERIAL-RESISTANCE TO IMIPENEM AND CIPROFLOXACIN IN A UNIVERSITY HOSPITAL

被引:26
作者
FASS, RJ [1 ]
BARNISHAN, J [1 ]
AYERS, LW [1 ]
机构
[1] OHIO STATE UNIV,COLL MED,DEPT PATHOL,DIV CLIN MICROBIOL,COLUMBUS,OH 43210
关键词
D O I
10.1093/jac/36.2.343
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We have continuously monitored the in-vitro activities of imipenem and ciprofloxacin against large numbers of non-fastidious clinical isolates. After eight years of use, 97-100% of Enterobacteriaceae and Acinetobactor baumannii remained susceptible to imipenem, but susceptibility of Pseudomonas aeruginosa declined from 100% to 91%. After six years of use, 94%-100% of Enterobacteriaceae (except Providencia stuartii) remained susceptible to ciprofloxacin but susceptibility of P. stuartii, A. baumannii and P. aeruginosa declined from 100% to 46%, 66% and 84%, respectively. Oxacillin-resistant staphylococci were considered to be resistant to imipenem and all beta-lactams. There were no quinolone-resistant staphylococci observed in 1986, but susceptibilities of Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus to ciprofloxacin decreased to 85-93% for oxacillin-susceptible strains and to 7-39% for oxacillin-resistant strains. Enterococcus faecalis has remained susceptible to imipenem and the modal MIC of ciprofloxacin has remained 1 mg/L; however, susceptibility to ciprofloxacin 2mg/L decreased from 94% to 64%. Imipenem-quinolone cross-resistance was observed for staphylococci but not for P. aeruginosa.
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页码:343 / 353
页数:11
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