EFFECTS OF FURYL-DIHYDROPYRIODINE-I ON CORONARY COLLATERAL CIRCULATION IN MYOCARDIAL-INFARCTION OF DOGS

被引：0
作者：
JIA, MJ
CHEN, SL
LIAO, YL
LIU, DQ
LI, LS
ZHAO, NP
机构：
[1] FOURTH MIL MED UNIV,XIJING HOSP,DEPT CARDIOL,XIAN 710032,PEOPLES R CHINA
[2] FOURTH MIL MED UNIV,DEPT PHARMACOL,XIAN 710032,PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1994年 / 15卷 / 05期
关键词：
DIHYDROPYRIDINES; MYOCARDIAL INFARCTION; CORONARY VESSELS; COLLATERAL CIRCULATION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 mu g.kg(-1)) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28.9+/-1.3 % to 15.3+/-1.2 % (p<0.01, n=6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia.
引用
收藏
页码：462 / 465
页数：4
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