CHARACTERIZATION OF 2 HUMAN MAMMARY CARCINOMAS, MT-1 AND MT-3, SUITABLE FOR INVIVO TESTING OF ETHER LIPIDS AND THEIR DERIVATIVES

被引:42
作者
NAUNDORF, H
REWASOWA, EC
FICHTNER, I
BUTTNER, B
BECKER, M
GORLICH, M
机构
[1] MAX DELBRUCK CENTRUM MOLEC MED,BUCH,GERMANY
[2] ACAD MED SCI,CANC RES CTR,MOSCOW,USSR
关键词
EXPERIMENTAL CHEMOTHERAPY; ETHER LIPIDS; HUMAN MAMMARY CARCINOMA; NUDE MICE;
D O I
10.1007/BF01831480
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The human mammary carcinomas MT-1 and MT-3 originate from surgical material and were transplanted in nude mice. Both tumors have been classified as estradiol- and progesterone receptor-negative. Therapeutic doses of hormones and anti-hormones remained without growth inhibitory effect. MT-1 and MT-3 proved to be sensitive to conventional cytostatic drugs used for treatment of mammary carcinomas; striking is their sensitivity to ether lipids. Therefore, they are considered suitable tumor models for this class of substances.
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页码:87 / 95
页数:9
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1980, EUR J CANCER, V16, P1513