ELECTROSTATIC COMPLEMENTARITY WITHIN THE SUBSTRATE-BINDING POCKET OF TRYPSIN

被引:173
作者
GRAF, L
JANCSO, A
SZILAGYI, L
HEGYI, G
PINTER, K
NARAYSZABO, G
HEPP, J
MEDZIHRADSZKY, K
RUTTER, WJ
机构
[1] CHINOIN PHARMACEUT & CHEM WORKS,H-1325 BUDAPEST,HUNGARY
[2] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1025 BUDAPEST,HUNGARY
[3] UNIV CALIF SAN FRANCISCO,HORMONE RES INST,SAN FRANCISCO,CA 94143
[4] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
关键词
D O I
10.1073/pnas.85.14.4961
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:4961 / 4965
页数:5
相关论文
共 25 条
[1]   STRUCTURE AND MECHANISM OF CHYMOTRYPSIN [J].
BLOW, DM .
ACCOUNTS OF CHEMICAL RESEARCH, 1976, 9 (04) :145-152
[2]   REFINED CRYSTAL-STRUCTURE OF BOVINE BETA-TRYPSIN AT 1.8 A RESOLUTION .2. CRYSTALLOGRAPHIC REFINEMENT, CALCIUM-BINDING SITE, BENZAMIDINE BINDING-SITE AND ACTIVE-SITE AT PH 7.0 [J].
BODE, W ;
SCHWAGER, P .
JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (04) :693-717
[3]  
BODE W, 1975, ENZYMES ELECTRON TRA, P3
[4]   THE CATALYTIC ROLE OF THE ACTIVE-SITE ASPARTIC-ACID IN SERINE PROTEASES [J].
CRAIK, CS ;
ROCZNIAK, S ;
LARGMAN, C ;
RUTTER, WJ .
SCIENCE, 1987, 237 (4817) :909-913
[5]  
CRAIK CS, 1984, J BIOL CHEM, V259, P4255
[6]   HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
KNILLJONES, J ;
LOWE, DM ;
WILKINSON, AJ ;
BLOW, DM ;
BRICK, P ;
CARTER, P ;
WAYE, MMY ;
WINTER, G .
NATURE, 1985, 314 (6008) :235-238
[8]   SELECTIVE ALTERATION OF SUBSTRATE-SPECIFICITY BY REPLACEMENT OF ASPARTIC ACID-189 WITH LYSINE IN THE BINDING POCKET OF TRYPSIN [J].
GRAF, L ;
CRAIK, CS ;
PATTHY, A ;
ROCZNIAK, S ;
FLETTERICK, RJ ;
RUTTER, WJ .
BIOCHEMISTRY, 1987, 26 (09) :2616-2623
[9]  
HENKEL JG, 1985, MOL GRAPHICS IBM PC
[10]   STRUCTURAL BASIS OF ACTIVATION AND ACTION OF TRYPSIN [J].
HUBER, R ;
BODE, W .
ACCOUNTS OF CHEMICAL RESEARCH, 1978, 11 (03) :114-122