THERAPEUTIC VALUE OF RECOMBINANT HUMAN GROWTH-HORMONE IN CHILDREN WITH CHRONIC-RENAL-FAILURE

被引：0

作者：

MEHLS, O ^{[1
]}

TONSHOFF, B ^{[1
]}

TONSHOFF, C ^{[1
]}

HAFFNER, D ^{[1
]}

BLUM, WF ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH,DIV PEDIAT NEPHROL,W-4300 ESSEN 1,GERMANY

来源：

MINERAL AND ELECTROLYTE METABOLISM | 1992年 / 18卷 / 2-5期

关键词：

GROWTH IN CHRONIC RENAL FAILURE; INSULIN-LIKE GROWTH FACTOR; RECOMBINANT HUMAN GROWTH HORMONE; RENAL TRANSPLANTATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In chronic renal failure (CRF), serum growth hormone (GH) levels are elevated due to a reduced renal metabolic clearance. Although the concentration of circulating GH is increased in CRF, insensitivity to GH is noted. This is mainly due to a decreased production of hepatic insulin-like growth factor (IGF)-I and an accumulation of its binding protein (IGFBP-3), both resulting in a low concentration of free active IGF-I. Treatment with recombinant human (rh) GH in doses of about 30 IU/m2/week, increases the serum concentration of IGF-I, normalizes somatomedin (IGF) bioactivity and leads to catch-up growth. The anabolic effects of rhGH are seen from an increase in muscle mass and a reduction of fat mass. rhGH treatment is also able to compensate for the growth-depressing effects of corticosteroids in animal studies and in children after renal transplantation.

引用

页码：320 / 324

页数：5

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