2 CASES OF HYPOTHYROIDISM ASSOCIATED WITH ALPHA-INTERFERON THERAPY

被引：20

作者：

TANIGUCHI, Y

MURAKAMI, T

NAKANISHI, K

TAMAI, M

MATSUURA, B

MASUMOTO, T

ONJI, M

TAJIRI, J

NOGUCHI, S

OHTA, Y

机构：

[1] Third Department of Internal Medicine, Ehime University School of Medicine, Ehime

[2] Noguchi Thyroid Clinic and Hospital Foundation, Beppu

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 03期

关键词：

AUTOIMMUNITY; THYROID FUNCTION;

D O I：

10.2169/internalmedicine.31.373

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alpha-interferon was used for anti-cancer or anti-viral therapy in two patients with pre-existing autoimmune thyroid disease and in seven patients with chronic viral hepatitis who had no history of thyroid dysfunction. Primary hypothyroidism developed in the two patients who had a history of autoimmune thyroid disease, while no changes in thyroid function were observed in the other seven patients. Modulation of the immune system by alpha-interferon may have been responsible for the development of hypothyroidism in these two patients. Therefore, autoantibodies to the thyroid and the thyroid function should be assessed in patients undergoing alpha-interferon therapy.

引用

页码：373 / 376

页数：4

共 10 条

[1] Fentiman I.S., Balkwill F.R., Thomas B.S., Russell M.J., Todd I., Bottazzo G.F., An autoimmune aetiology of hypothyroidism following interferon therapy for breast cancer, Eur J Cancer Clin Oncol, 24, (1988)
[2] Conlon K.C., Urba W.J., Smith J.W., Steis R.G., Longo D.L., Clark J.W., Exacerbation of symptoms of autoimmune disease in patients receiving alpha-interferon therapy, Cancer, 65, (1990)
[3] Davis G.L., Hoofnagle J.H., Interferon in viral hepatitis
[4] Role in pathogenesis and treatment, Hepatology, 6, (1986)
[5] Burman P., Totterman T.H., Oberg K., Karlsson F.A., Thyroid autoimmunity in patients on long term therapy with leukocyte-derived interferon, J Clin Endocrinol Metab, 63, (1986)
[6] Bhakri H., Sriskandan K., Davis T., Pettingale K., Tee D., Recombinant gamma-interferon and autoimmune thyroid disease, Lancet, ii, (1985)
[7] Remi J., Salamero J., Michel-Bechet M., Charreive J., Experimental autoimmune thyroiditis induced by a recombinant interferon-y, Immunol Today, 8, (1987)
[8] Mowat A.M., Interferon and class II MHC antigen expression in autoimmunity, Lancet, ii, (1985)
[9] Nagayama Y., Izumi M., Ashizawa K., Et al., Inhibitory effect of interferon-y on the response of human thyrocytes to thyrotropin (TSH) stimulation: Relationship between the response to TSH and the expression of DR antigen, J Clin Endocrinol Metab, 64, (1987)
[10] Murakami T., Tajiri J., Noguchi S., Et al., Effects of interferon on cultured Graves' thyrocytes, Folia Endocrinol, 66, (1990)

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