OXIDIZED LOW-DENSITY LIPOPROTEINS INDUCE IRON RELEASE FROM ACTIVATED MYOGLOBIN

被引：26
|
作者：
RICEEVANS, C
GREEN, E
PAGANGA, G
COOPER, C
WRIGGLESWORTH, J
机构：
[1] UNIV LONDON UNIV COLL,SCH MED,SCH MED,RAYNE INST,DEPT PAEDIAT,LONDON WC1E 6JJ,ENGLAND
[2] KINGS COLL LONDON,CTR MET BIOL & MED,DIV LIFE SCI,LONDON W8 7AH,ENGLAND
来源：
FEBS LETTERS | 1993年 / 326卷 / 1-3期
关键词：
OXIDIZED LDL; MONOHYDROXAMATE; DESFERRIOXAMINE; IRON; MYOGLOBIN; LOW DENSITY LIPOPROTEIN;
D O I：
10.1016/0014-5793(93)81786-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent reports have detected the presence of iron in human atherosclerotic lesions [Biochem. J. 286 (1992) 901-905]. This study provides evidence for a biochemical mechanism whereby iron is released from myoglobin by low density lipoprotein (LDL) which has become oxidised by the ferryl myoglobin species. The haem destabilisation and iron release are inhibited by monohydroxamate compounds and desferrioxamine through their ability to inhibit the propagation of LDL oxidation. Thus, iron may derive from the myoglobin released from ruptured cells in the oxidising environment of the atherosclerotic lesion.
引用
收藏
页码：177 / 182
页数：6
相关论文
共 50 条
  • [1] Oxidized low-density lipoproteins induce apoptosis in macrophages
    Niu, XL
    Zhang, XW
    Guo, ZG
    ACTA PHARMACOLOGICA SINICA, 1996, 17 (05): : 467 - 470
  • [2] OXIDIZED LOW-DENSITY LIPOPROTEINS RELEASE ENDOTHELIN FROM THE HUMAN AND PORCINE ENDOTHELIUM
    BOULANGER, C
    HAHN, AWA
    LUSCHER, TF
    CIRCULATION, 1990, 82 (04) : 225 - 225
  • [3] OXIDIZED LOW-DENSITY LIPOPROTEINS INDUCE MESSENGER-RNA EXPRESSION AND RELEASE OF ENDOTHELIN FROM HUMAN AND PORCINE ENDOTHELIUM
    BOULANGER, CM
    TANNER, FC
    BEA, ML
    HAHN, AWA
    WERNER, A
    LUSCHER, TF
    CIRCULATION RESEARCH, 1992, 70 (06) : 1191 - 1197
  • [4] OXIDIZED LOW-DENSITY LIPOPROTEINS AND ATHEROGENESIS
    LEAKE, DS
    BRITISH HEART JOURNAL, 1993, 69 (06): : 476 - 478
  • [5] Oxidized low-density lipoproteins induce apoptosis in aortic and endocardial endothelial cells
    Guo, ZG
    Niu, XL
    Guo, X
    ACTA PHARMACOLOGICA SINICA, 1997, 18 (06): : 525 - &
  • [6] Oxidized low-density lipoproteins induce apoptosis in vascular smooth muscle cells
    刘文兰
    郭迅
    郭兆贵
    ActaPharmacologicaSinica, 1998, (03) : 50 - 52
  • [7] Oxidized low-density lipoproteins induce apoptosis in aortic and endocardial endothelial cells
    郭兆贵
    牛喜林
    郭迅
    Acta Pharmacologica Sinica, 1997, (06) : 45 - 48
  • [8] Oxidized low-density lipoproteins induce apoptosis in vascular smooth muscle cells
    Liu, WL
    Guo, X
    Guo, ZG
    ACTA PHARMACOLOGICA SINICA, 1998, 19 (03): : 245 - +
  • [9] Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer
    Diakowska, Dorota
    Grabowski, Krzysztof
    Nienartowicz, Miroslaw
    Zarebski, Pawel
    Fudalej, Kamila
    Markocka-Maczka, Krystyna
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2015, 2015
  • [10] Searching for oxidized low-density lipoproteins in vivo
    Itabe, H
    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2005, 37 (01) : 1 - 8
12345