THYROID-HORMONE DIFFERENTIALLY AFFECTS MESSENGER-RNA LEVELS OF CA-ATPASE ISOZYMES OF SARCOPLASMIC-RETICULUM IN FAST AND SLOW SKELETAL-MUSCLE

被引：48
作者：
SIMONIDES, WS
VANDERLINDEN, GC
VANHARDEVELD, C
机构：
[1] Laboratory for Physiology, Free University, 1081 BT Amsterdam
来源：
FEBS LETTERS | 1990年 / 274卷 / 1-2期
关键词：
Ca-ATPase activity; Ca-ATPase isozyme; Rat skeletal muscle; Sarcoplasmic reticulum; Thyroid hormone;
D O I：
10.1016/0014-5793(90)81332-I
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
mRNA levels for the type I and type II isoforms of sarcoplasmic reticulum (SR) Ca-ATPase were determined in soleus (SOL) and extensor digitorum longus (EDL) muscle of euthyroid (normal), hypothyroid, and hyperthyroid rats. Total Ca-ATPase mRNA content of hyperthyroid muscle was 1.5-fold (EDL) and 6-fold (SOL) higher compared to hypothyroid muscle, with corresponding increases in total SR Ca-ATPase activity. EDL contained only type II Ca-ATPase mRNA. In SOL type I mRNA was the major form in hypothyroidism (98%), but the type II mRNA content was stimulated 150-fold by T3, accounting for 50% of the Ca-ATPase mRNA in hyperthyroidism. © 1990.
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页码：73 / 76
页数：4
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