STUDIES ON SELENIUM-RELATED COMPOUNDS .5. CYTOGENETIC EFFECT AND REACTIVITY WITH DNA

被引：62

作者：

NAKAMURO, K

YOSHIKAWA, K

SAYATO, Y

KURATA, H

TONOMURA, M

TONOMURA, A

机构：

[1] NATL INST HYG SCI, DEPT MICROBIOL, SETAGAYA KU, TOKYO 158, JAPAN

[2] TOKYO MED & DENT UNIV, MED RES INST, DEPT CYTOGENET, BUNKYO KU, TOKYO 113, JAPAN

[3] NATL INST HYG SCI, DEPT HYG CHEM, SETAGAYA KU, TOKYO 158, JAPAN

来源：

MUTATION RESEARCH | 1976年 / 40卷 / 03期

关键词：

D O I：

10.1016/0165-1218(76)90042-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Five Se compounds, Na2SeO4, H2SeO4, Na2SeO3, H2SeO3 and SeO2, were tested for their capacity to induce chromosome aberrations in cultured human leukocytes and for their reactivity with DNA by a rec-assay system and inactivation of transforming activity in Bacillus subtilis. Chromosome-breaking activity was significantly higher for the compounds with 4-valent than with 6-valent Se, the efficiency being in the decreasing order H2SeO3 > Na2SeO3 > SeO2 .mchgt. H2SeO4 > Na2SeO4. Rec assay using B. subtilis with different recombination capacities suggested that damage to DNA was produced by selenites but not by selenates. The reactivity of selenites with DNA was also indicated by a significant loss of transformation of the tryptophan marker of B. subtilis DNA treated with H2SeO3 and SeO2.

引用

页码：177 / 183

页数：7

共 6 条

[1] IN-VITRO AND HOST-MEDIATED REC-ASSAY PROCEDURES FOR SCREENING CHEMICAL MUTAGENS - AND PHLOXINE, A MUTAGENIC RED DYE DETECTED [J].