IRINOTECAN, FLUOROURACIL AND LEUCOVORIN IN PATIENTS WITH METASTATIC COLORECTAL CANCER

被引：0

作者：

Davidov, Deyan ^{[1
]}

机构：

[1] Med Univ, Dept Chemotherapy Oncol Ctr, 1 St Kliment Ohridsky Str, Pleven 5000, Bulgaria

来源：

JOURNAL OF IMAB | 2008年 / 14卷 / 01期

关键词：

Irinotecan; Colorectal cancer; Treatment; Survival;

D O I：

10.5272/jimab.14-1-2010.48

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Irinotecan is a topoisomerase I inhibitor that prolongs survival as second-line therapy in patients with metastatic colorectal cancer, treated with Fluorouracil and Leucovorin only. Aim: The aim of this study was to evaluate the efficacy and toxicity of the combination Irinotecan, Fluorouracil and Leucovorin. Methods: In the period 2006-2007 34 patients with metastatic colorectal cancer entered the study. The treatment schedule consists of Irinotecan 180 mg/m2 day 1, Fluorouracil 400 mg/m2 day 1 and 2 and Leucovorin 200 mg/m2 day 1 and 2 every 14 days. Results: Overall response rate was 36,7% with three complete remissions. Median survival was 20,3 months. Diarrhea, vomiting and mucositis were most common side effects. Conclusions: That data suggest that the addition of Irinotecan to Fluorouracil and Leucovorin will offer opportunity to treat patients with metastatic colorectal cancer.

引用

页码：48 / 50

页数：3

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